Emotional adjustment in amyotrophic lateral sclerosis (ALS)
Emotional adjustment in amyotrophic lateral sclerosis (ALS)
复制标题
DOI：
10.1007/s00415-011-6191-x
复制
发表时间：
2012-02-01
影响因子：
6
通讯作者：
Ludolph, Albert C.
中科院分区：
文献类型：
--
作者：
Lule, Dorothee;Pauli, Sandra;Ludolph, Albert C.
尽管有毁灭性的运动障碍，但大量肌萎缩侧索硬化症（ALS）患者仍能保持良好的心理社会适应。在这里，我们调查了这是否是特定于ALS或更普遍的晚期疾病的特征。在30例ALS患者，29例姑息治疗的癌症患者和29名年龄，性别和教育水平匹配的健康对照者中进行了心理社会适应调查。主观生活质量（sQoL），抑郁症状的程度和应对作为心理社会适应的措施进行了评估。描述了个性因素。ALS和癌症患者表现出良好的心理社会适应。主观生活质量和抑郁没有显着差异。两个患者组均表现出良好的sQoL。两组患者的轻度抑郁症状水平相似，均未表现出临床相关抑郁。ALS患者比癌症患者表达较少的积极应对策略，这是由性别差异解释的。两组患者对疾病的心理社会适应能力相当。总的来说，在绝症患者中，对预后的心理反应与神经生物学变化无关（例如，与ALS中的亚临床缺陷相关）或与身体衰退相关。
Despite the devastating motor impairment, a significant number of patients with amyotrophic lateral sclerosis (ALS) maintain a good psychosocial adjustment. Here we investigated whether this is specific for ALS or a more general characteristic of terminal disease. Psychosocial adjustment was investigated in 30 ALS patients, 29 cancer patients in palliative treatment and 29 age-, gender- and level of education-matched healthy controls. Subjective quality of life (sQoL), degree of depressive symptoms and coping were evaluated as measures of psychosocial adjustment. Personality factors were described. ALS and cancer patients showed a good psychosocial adjustment. Subjective QoL and depression did not differ significantly. Both patient groups presented a good sQoL. The level of mild depressive symptoms in both patient groups was similar and none showed clinically relevant depression. ALS patients expressed fewer active coping strategies than cancer patients which were explained by gender differences. Both patient groups showed comparable psychosocial adjustment to their disease. Overall, in terminally ill patients the psychological response to the prognosis is not associated with neurobiological changes (e.g., associated with subclinical deficits in ALS) or with physical decline.