Wearable Passive Samplers for Assessing Environmental Exposure to Organic Chemicals: Current Approaches and Future Directions.
Wearable Passive Samplers for Assessing Environmental Exposure to Organic Chemicals: Current Approaches and Future Directions.
复制标题
用于评估有机化学品环境暴露的可穿戴被动采样器：当前方法和未来方向。
DOI：
10.1007/s40572-023-00392-w
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发表时间：
2023
影响因子：
7.9
通讯作者：
Pollitt,KrystalJGodri
中科院分区：
文献类型：
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作者：
Okeme,JosephO;Koelmel,JeremyP;Johnson,Emily;Lin,ElizabethZ;Gao,Dong;Pollitt,KrystalJGodri
审查的目的我们不断暴露于空气中污染物的动态混合物，这些污染物因地点而异。了解这些复杂混合物的成分多样性以及我们每个人所暴露的水平需要全面的暴露评估。由于涉及主动空气采样和逐个化学品分析的传统测量方法所带来的后勤和分析挑战，基于人口的研究往往缺乏这种综合分析。这篇综述的目的是提供一个概述可穿戴被动采样器作为替代工具，主动采样器在环境健康研究。该综述强调了使用可穿戴被动采样器评估个人暴露于有机化学品的进展和挑战，并进一步提出了一个框架，使暴露的定量测量和扩大使用这种监测方法的人口scale.Recent FindingsOverall，可穿戴被动采样器是有前途的工具，用于评估个人暴露于环境污染物，这一点通过近年来越来越多地采用和使用基于硅树脂的器件而显而易见。当与高通量化学分析相结合时，这些暴露评估工具为提高我们评估个人暴露于复杂混合物的能力提供了机会。大多数用于评估暴露于半挥发性有机化学品的可穿戴被动采样器的设计目前是未经校准的，因此，主要用于定性研究。使用可穿戴采样器进行定量暴露评估的挑战主要在于校准这些可穿戴设备的固有复杂性。关于它们在各种条件下的表现以及暴露估计的不确定性，仍然存在问题。随着这些采样器越来越受欢迎，了解化学品的吸收动力学以及不同的环境和气象条件是至关重要的，这些条件可能会引入可变性。该综述介绍了评估个人接触环境化学品的最新技术。随着越来越多的研究校准可穿戴采样器，这些工具有望在个人和人群水平上定量评估暴露。
Purpose of ReviewWe are continuously exposed to dynamic mixtures of airborne contaminants that vary by location. Understanding the compositional diversity of these complex mixtures and the levels to which we are each exposed requires comprehensive exposure assessment. This comprehensive analysis is often lacking in population-based studies due to logistic and analytical challenges associated with traditional measurement approaches involving active air sampling and chemical-by-chemical analysis. The objective of this review is to provide an overview of wearable passive samplers as alternative tools to active samplers in environmental health research. The review highlights the advances and challenges in using wearable passive samplers for assessing personal exposure to organic chemicals and further presents a framework to enable quantitative measurements of exposure and expanded use of this monitoring approach to the population scale.Recent FindingsOverall, wearable passive samplers are promising tools for assessing personal exposure to environmental contaminants, evident by the increased adoption and use of silicone-based devices in recent years. When combined with high throughput chemical analysis, these exposure assessment tools present opportunities for advancing our ability to assess personal exposures to complex mixtures. Most designs of wearable passive samplers used for assessing exposure to semi-volatile organic chemicals are currently uncalibrated, thus, are mostly used for qualitative research. The challenge with using wearable samplers for quantitative exposure assessment mostly lies with the inherent complexity in calibrating these wearable devices. Questions remain regarding how they perform under various conditions and the uncertainty of exposure estimates. As popularity of these samplers grows, it is critical to understand the uptake kinetics of chemicals and the different environmental and meteorological conditions that can introduce variability.SummaryWearable passive samplers enable evaluation of exposure to hundreds of chemicals. The review presents the state-of-the-art of technology for assessing personal exposure to environmental chemicals. As more studies calibrate wearable samplers, these tools present promise for quantitatively assessing exposure at both the individual and population levels.