Spatial reconstruction of trajectories of an array of recording microelectrodes

Spatial reconstruction of trajectories of an array of recording microelectrodes
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DOI:
10.1152/jn.00581.2004
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发表时间:
2005-04-01
影响因子:
2.5
通讯作者:
Georgopoulos, AP
Georgopoulos, AP
中科院分区:
医学3区
文献类型:
--
作者:
Naselaris, T;Merchant, H;Georgopoulos, AP

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We present a method for estimating the locations of sites visited by an array of microelectrodes. The method relies on visualization of tracks made by electrodes coated in a fluorescent dye. These tracks are used to estimate the parameters of a simple geometrical model that generates coordinates for each recording site. We describe several ways to measure the error of this procedure and present experimental results from recordings in the motor cortex of macaque monkeys that suggest that errors are of the order of 230 mu n. We also introduce a coordinate transformation that takes into account the convoluted structure of the cortex near sulci to conveniently visualize recording site locations in a rectilinear representation. This method greatly extends the capabilities of microelectrodes for studying the three-dimensional structure of topographic maps in the cortex.