Elevated mycobacterium avium subsp. paratuberculosis (MAP) antibody titer in Japanese multiple sclerosis
Elevated mycobacterium avium subsp. paratuberculosis (MAP) antibody titer in Japanese multiple sclerosis
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DOI：
10.1016/j.jneuroim.2021.577701
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发表时间：
2021-09-08
影响因子：
3.3
通讯作者：
Kira, Jun-ichi
中科院分区：
文献类型：
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作者：
Hayashi, Fumie;Isobe, Noriko;Kira, Jun-ichi
目的探讨禽分枝杆菌禽亚种抗体的产生。为了解多发性硬化（MS）患者的临床特征和人类白细胞抗原（HLA）等位基因与副结核抗原（MAP）的关系，检测了103例MS患者和50例健康对照者血清中抗MAP三种多肽和两种人源多肽的IgG抗体。MS患者具有比HC更高的针对MAP 2694295 -303（MAP 2694 IgG）的IgG水平，而其他抗体相当。多变量分析表明，较高的MAP 2694-IgG滴度与较高的EDSS评分相关，但与HLA等位基因或乳制品摄入量无关。针对MAP的免疫应答可能使MS残疾恶化。
To investigate whether antibody production against mycobacterium avium subsp. paratuberculosis (MAP) is related to clinical characteristics of multiple sclerosis (MS) and human leukocyte antigen (HLA) alleles, IgG antibody against three MAP peptides and two human peptides homologous to MAP were measured in sera from 103 MS patients and 50 healthy controls (HCs). MS patients had higher IgG levels against MAP2694295-303 (MAP2694IgG) than HCs, while the other antibodies were comparable. Multivariate analysis demonstrated that higher MAP2694-IgG titers were associated with higher EDSS scores, but not with HLA alleles or dairy product consumption. Immune response against MAP may worsen MS disability.