Effect of Actinomycin D on the Infectivity of Trypanosoma cruzi
Effect of Actinomycin D on the Infectivity of Trypanosoma cruzi
复制标题
放线菌素D对克氏锥虫感染力的影响
DOI：
10.1038/2071004a0
复制
发表时间：
1965
期刊：
影响因子：
64.8
通讯作者：
O. Castellani
中科院分区：
文献类型：
--
作者：
J. F. Fernandes;M. Halsman;O. Castellani
对T.已经通过几种方法在小鼠中获得Cruzi 1 -4。所有这些程序导致有限的保护，其特征在于血液中出现寄生虫。使用杀死的鞭毛虫诱导很少或没有抵抗力的毒力strain 1，5，表明轻微的宿主感染是一个不可或缺的先决条件，甚至部分免疫的发展。
PARTIAL immunity against a virulent and lethal strain of T. cruzi has been obtained in mice by several procedures1–4. All these procedures lead to a limited protection and are characterized by the appearance of parasites in the blood. The use of killed flagellates induces little or no resistance against the virulent strain1,5, suggesting that a mild host infection is an indispensable prerequisite for the development of even partial immunity.