Discordance between traditional pathologic and energy metabolic changes in very early Alzheimer's disease - Pathophysiological implications
Discordance between traditional pathologic and energy metabolic changes in very early Alzheimer's disease - Pathophysiological implications
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DOI：
10.1111/j.1749-6632.1999.tb07852.x
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发表时间：
1999-01-01
期刊：
影响因子：
--
通讯作者：
Kuhl, DE
中科院分区：
文献类型：
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作者：
Minoshima, S;Cross, DJ;Kuhl, DE
最近对极早期阿尔茨海默病的病理和代谢研究表明，传统的病理变化和葡萄糖代谢减少之间的分布是不一致的。阿尔茨海默病非常早期的传统病理改变发生在内侧颞叶，特别是内嗅皮层。1相反，非常早期的葡萄糖代谢减少发生在外侧联合皮质和后扣带皮质。2本研究利用正电子发射断层扫描(PET)研究了代谢改变与病理改变之间不一致的可能的病理生理机制。
Recent pathologic and metabolic studies of very early Alzheimer’s disease suggest a discordance in the distribution between traditional pathologic changes and glucose metabolic reduction. Traditional pathologic changes in very early stages of AD are shown to occur in the medial temporal lobe, specifically in the entorhinal cortex. 1 In contrast, very early glucose metabolic reductions occur in the lateral association cortices and posterior cingulate cortex. 2 This study addresses the possible pathophysiological mechanisms explaining such discordance between metabolic and pathologic changes using positron emission tomography (PET).