Regulation of cardiac ion channels by signaling complexes: role of modified leucine zipper motifs
Regulation of cardiac ion channels by signaling complexes: role of modified leucine zipper motifs
复制标题
DOI：
10.1016/j.yjmcc.2004.04.014
复制
发表时间：
2004-09-01
影响因子：
5
通讯作者：
Catterall, WA
中科院分区：
文献类型：
--
作者：
Hulme, JT;Scheuer, T;Catterall, WA
蛋白质磷酸化对离子通道的调节是一个由蛋白激酶和磷酸化蛋白磷酸酶相互对立的作用精确控制的动态过程。已被公认的是，将这些信号转导酶定位于离散的亚细胞室或底物是确保信号事件对局部刺激反应的特异性的重要调控机制。这些酶的区隔是通过与锚定或接头蛋白结合来实现的，这些锚定或接头蛋白将它们定位于亚细胞细胞器，或通过蛋白质-蛋白质相互作用将它们直接拴在目标底物上。最近，修饰的亮氨酸拉链基序通过锚定蛋白被描述为三个心脏离子通道家族的新作用：兰诺定敏感的钙离子释放通道、电压门控钙通道和延迟整流钾通道。本文将对这些大分子信号复合体在正常心脏和疾病心脏中调节心脏离子通道的研究进展作一综述。(C)2004爱思唯尔科学有限公司。保留所有权利。
Modulation of ion channels by protein phosphorylation is a dynamic process precisely controlled by the opposing actions of protein kinases and phosphoprotein phosphatases. It is well accepted that the targeting and localization of such signaling enzymes to discrete subcellular compartments or substrates is an important regulatory mechanism ensuring specificity of signaling events in response to local stimuli. Compartmentalization of these enzymes is achieved through association with anchoring or adaptor proteins that target them to subcellular organelles or tether them directly to target substrates via protein-protein interactions. Recently, a novel role for modified leucine zipper motifs in targeting kinases and phosphatases via anchoring proteins has been described for three families of cardiac ion channels: ryanodine-sensitive calcium (Ca2+) release channels, voltage-gated Ca2+ channels, and delayed rectifier potassium (K+) channels. This review will summarize the recent advances made on the regulation of cardiac ion channels by these macromolecular signaling complexes in the normal and diseased heart. (C) 2004 Elsevier Science Ltd. All rights reserved.