Surface Nanopore Engineering of 2D MXenes for Targeted and Synergistic Multitherapies of Hepatocellular Carcinoma
Surface Nanopore Engineering of 2D MXenes for Targeted and Synergistic Multitherapies of Hepatocellular Carcinoma
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二维 MXene 的表面纳米孔工程用于肝细胞癌的靶向协同多疗法
DOI：
10.1002/adma.201706981
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发表时间：
2018-06-20
影响因子：
29.4
通讯作者：
Yang, Tian
中科院分区：
文献类型：
--
作者：
Li, Zhenli;Zhang, Han;Yang, Tian
肝细胞癌（HCC）是最常见和最致命的胃肠道恶性肿瘤之一。鉴于其对传统系统化疗的不敏感性，迫切需要有效治疗HCC的新治疗策略。在这里，报道了一种新型的基于2D MXene的复合纳米平台的开发，用于高效和协同的化疗和光热热疗对抗HCC。为MXene的表面功能化开发了一种表面纳米孔工程策略，其实现了在2D Ti 3C 2 MXene（Ti3C2@mMSNs）表面上均匀涂覆薄介孔二氧化硅层。这种策略赋予MXenes良好定义的中孔，用于按需药物释放/递送，增强的亲水性/分散性，以及用于靶向工程的丰富表面化学。系统的体外和体内评价已经证明了精氨酸-甘氨酸-天冬氨酸（RGD）靶向Ti3C2@mMSNs进入肿瘤的高活性靶向能力，以及协同化疗（由介孔壳贡献）和光热热疗（由Ti 3C 2 MXene核心贡献）完全根除肿瘤而无明显复发。这项工作不仅通过开发基于MXene的复合纳米平台提供了一种有效对抗HCC的新策略，而且还为通过表面纳米孔工程扩展MXene的生物医学应用铺平了新的道路。
Hepatocellular carcinoma (HCC) is one of the most common and deadly gastrointestinal malignancies. Given its insensitivity to traditional systematic chemotherapy, new therapeutic strategies for efficient HCCs treatment are urgently needed. Here, the development of a novel 2D MXene‐based composite nanoplatform for highly efficient and synergistic chemotherapy and photothermal hyperthermia against HCC is reported. A surface‐nanopore engineering strategy is developed for the MXenes’ surface functionalization, which achieves the uniform coating of a thin mesoporous‐silica layer onto the surface of 2D Ti3C2 MXene (Ti3C2@mMSNs). This strategy endows MXenes with well‐defined mesopores for on‐demand drug release/delivery, enhanced hydrophilicity/dispersity, and abundant surface chemistry for targeting engineering. Systematic in vitro and in vivo evaluations have demonstrated the high active‐targeting capability of arginine‐glycine‐aspartic acid (RGD)‐targeting Ti3C2@mMSNs into tumor, and the synergistic chemotherapy (contributed by the mesoporous shell) and photothermal hyperthermia (contributed by the Ti3C2 MXene core) completely eradicate the tumor without obvious reoccurrence. This work not only provides a novel strategy for efficiently combating HCC by developing MXene‐based composite nanoplatforms, but also paves a new way for extending the biomedical applications of MXenes by surface‐nanopore engineering.