Structural biology of cytokines, their receptors, and signaling complexes: implications for the immune and neuroendocrine circuit.
Structural biology of cytokines, their receptors, and signaling complexes: implications for the immune and neuroendocrine circuit.
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细胞因子、其受体和信号复合物的结构生物学：对免疫和神经内分泌回路的影响。
DOI：
10.1159/000058654
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Walter,MR
中科院分区：
文献类型：
--
作者：
Walter,MR
细胞防御、新陈代谢和生长等复杂的生物过程需要一个高效的通信网络来协调和控制大量不同细胞的反应。调节肌肉、骨和软骨的生长和代谢、造血和神经生成的许多信号由小α-螺旋细胞外信号蛋白家族递送。这些蛋白质的不同功能，现在统称为细胞因子，反映在它们的许多名称中，包括集落刺激因子，激素，生长因子，干扰素，白细胞介素，淋巴因子和神经营养因子。这种通用的命名法可能更具描述性，因为正如前面章节所讨论的，许多这些分子及其受体在内分泌系统、免疫系统和神经系统中是共享的。当一个细胞产生的细胞因子随后被另一个细胞上的特异性受体识别时，细胞通信发生。细胞表面受体将细胞外蛋白质的结合转化为细胞质信号，细胞质信号触发适当的细胞反应。本章将比较和对比的结构特征的细胞因子和细胞因子受体复合物，更经典地与免疫系统与那些更经典地与神经内分泌系统。
The complex biological processes of cellular defense, metabolism, and growth require an efficient commmunication network to coordinate and control the responses of huge numbers of different cells. Many of the signals which regulate the growth and metabolism of muscle, bone and cartilage, hematopoiesis, and neuropoiesis are delivered by a family of small a-helical extracellular signaling proteins. The diverse functions of these proteins, now collectively called cytokines, are reflected in their many names which include colony stimulating factors, hormones, growth factors, interferons, interleukins, lymphokines, and neurotrophic factors. This general nomenclature may be more descriptive since, as discussed in earlier chapters, many of these molecules and their receptors are shared among the endocrine, immune, and nervous systems. Cellular communication occurs when a cytokine produced by one cell is subsequently recognized by specific receptors on another cell. The cell surface receptors transduce the binding of the extracellular proteins into cytoplasmic signals which trigger the appropriate cellular responses. This chapter will compare and contrast the structural features of cytokines and cytokine receptor complexes that are more classically associated with the immune system with those more classically associated with the neuroendocrine system.