Early clearance vs persistence of de novo donor-specific antibodies following lung transplantation
Early clearance vs persistence of de novo donor-specific antibodies following lung transplantation
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DOI：
10.1111/ctr.13028
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发表时间：
2017-08-01
影响因子：
2.1
通讯作者：
Gaber, A. Osama
中科院分区：
文献类型：
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作者：
Islam, Ana K.;Sinha, Neeraj;Gaber, A. Osama
背景：肺移植后新生供者特异性抗体(DnDSA)的自然病史尚未得到很好的描述。我们试图确定与dnDSA相关的发生率和危险因素，并比较移植后一过性(或孤立)dnDSA与持续性dnDSA受者之间的结果。方法：对2009年1月至2013年7月所有肺移植进行单中心回顾。DSA在第一年进行了8次测试，此后每4个月进行一次测试。结果：中位随访时间为18个月(范围为1-61个月)，333例首次肺移植受者中有24.6%发生dnDSA。民族、人类白细胞抗原-DQ不匹配、移植后血小板输注、肺分配评分&60分与dnDSA相关(P
Background: The natural history of de novo donor-specific antibodies (dnDSA) after lung transplantation is not well-described. We sought to determine the incidence and risk factors associated with dnDSA and compare outcomes between recipients with transient (or isolated) vs persistent dnDSA after transplantation.Methods: A single-center review of all lung transplants from 1/2009-7/2013. DSAs were tested eight times in the first year and every 4 months thereafter. Outcomes examined included acute rejection and graft failure.Results: Median follow-up was 18 months (range: 1-61 months), and 24.6% of 333 first-time lung-only transplant recipients developed a dnDSA. Ethnicity, HLA-DQ mismatches, post-transplantation platelet transfusion and Lung Allocation Score >60 were associated with dnDSA (P