No Moderating Effect of 5-HTTLPR on Associations Between Antenatal Anxiety and Infant Behavior
No Moderating Effect of 5-HTTLPR on Associations Between Antenatal Anxiety and Infant Behavior
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DOI：
10.1016/j.jaac.2013.02.010
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发表时间：
2013-05-01
影响因子：
13.3
通讯作者：
Murphy, Susannah E.
中科院分区：
文献类型：
--
作者：
Braithwaite, Elizabeth C.;Ramchandani, Paul G.;Murphy, Susannah E.
目的：母亲产前焦虑与后代行为障碍的风险增加有关。最近的研究表明，母亲产前焦虑对6个月婴儿气质的影响是由5-羟色胺转运体多态性5-HTTLPR调节的，短等位基因的携带者更容易受到母亲产前焦虑的不良行为结果的影响。然而，这些研究结果还有待于复制和推广到婴儿期以后。本研究的目的是在一项大型人群队列研究中评估这种潜在的调节剂（5-HTTLPR），并确定其影响是否持续到儿童期和青春期早期。方法：雅芳儿童和父母纵向研究（ALSPAC）队列数据（N = 3，946）被用来评估5-HTTLPR基因型是否调节自我报告的母亲产前焦虑之间的关联，（皇冠脆指数）在怀孕，和儿童气质在6个月（婴儿气质问卷），以及后来的行为和情绪问题的优势和困难问卷从4岁到13岁。结果如下：我们没有发现证据表明5-HTTLPR多态性调节了母亲产前焦虑对6个月婴儿气质或婴儿从童年到青春期的行为和情绪问题的影响。结论：我们的研究结果，基于一个大的前瞻性社区样本，评估儿童从婴儿期到青春期早期，提供了一个彻底的测试，但没有证据表明，5-HTTLPR的母亲产前焦虑的影响的遗传调节。J. Am. Acad.儿童青少年精神病学，2013;52（5）：519-526。
Objective: Maternal antenatal anxiety is associated with an increased risk of behavioral disturbances in offspring. Recent work has suggested that the effect of maternal antenatal anxiety on infant temperament at 6 months is moderated by the serotonin transporter polymorphism 5-HTTLPR, with carriers of the short allele more susceptible to the adverse behavioral outcomes of maternal antenatal anxiety. These findings, however, are yet to be replicated and extended beyond infancy. The aim of the current study was to assess this same potential moderator (5-HTTLPR) in a large population-based cohort study, and to determine whether or not the effects persist into childhood and early adolescence. Method: Data from the Avon Longitudinal Study of Children and Parents (ALSPAC) cohort (N = 3,946) were used to assess whether the 5-HTTLPR genotype moderated the association between self-reported maternal antenatal anxiety (Crown Crisp Index) in pregnancy, and child temperament at 6 months (Infant Temperament Questionnaire), and also later behavioral and emotional problems on the Strengths and Difficulties Questionnaire from age 4 to 13 years. Results: We found no evidence to suggest that the 5-HTTLPR polymorphism moderated the effects of maternal antenatal anxiety on infant temperament at 6 months or infant behavioral and emotional problems from childhood through to adolescence. Conclusion: Our results, based on a large prospective community sample that assessed children from infancy to early adolescence, provide a thorough test of, but no evidence for, a genetic moderation of the effects of maternal antenatal anxiety by 5-HTTLPR. J. Am. Acad. Child Adolesc. Psychiatry, 2013;52(5):519-526.