Regeneration and Recovery after Acetaminophen Hepatotoxicity.
Regeneration and Recovery after Acetaminophen Hepatotoxicity.
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对乙酰氨基酚肝毒性后的再生与恢复。
DOI：
10.3390/livers3020021
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发表时间：
2023-06
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
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作者：
Liver regeneration is a compensatory response to tissue injury and loss. It is known that liver regeneration plays a crucial role in recovery following acetaminophen (APAP)-induced hepatotoxicity, which is the major cause of acute liver failure (ALF) in the US. Regeneration increases proportional to the extent of liver injury upon APAP overdose, ultimately leading to regression of injury and spontaneous recovery in most cases. However, severe APAP overdose results in impaired liver regeneration and unchecked progression of liver injury, leading to failed recovery and mortality. Inter-communication between various cell types in the liver is important for effective regenerative response following APAP hepatotoxicity. Various non-parenchymal cells such macrophages, stellate cells, and endothelial cells produce mediators crucial for proliferation of hepatocytes. Liver regeneration is orchestrated by synchronized actions of several proliferative signaling pathways involving numerous kinases, nuclear receptors, transcription factors, transcriptional co-activators, which are activated by cytokines, growth factors, and endobiotics. Overt activation of anti-proliferative signaling pathways causes cell-cycle arrest and impaired liver regeneration after severe APAP overdose. Stimulating liver regeneration by activating proliferating signaling and suppressing anti-proliferative signaling in liver can prove to be important in developing novel therapeutics for APAP-induced ALF.
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影响因子：
13.5
作者：
Apte, Udayan;Gkretsi, Vasiliki;Bowen, William C.;Mars, Wendy M.;Luo, Jian-Hua;Donthamsetty, Shashikiran;Orr, Ann;Monga, Satdarshan P. S.;Wu, Chuanyue;Michalopoulos, George K.
通讯作者：
Michalopoulos, George K.
影响因子：
--
作者：
Borude P;Bhushan B;Apte U
通讯作者：
Apte U
影响因子：
23.9
作者：
Ben-Moshe, Shani;Veg, Tamar;Itzkovitz, Shalev
通讯作者：
Itzkovitz, Shalev
影响因子：
6
作者：
Borude, Prachi;Bhushan, Bharat;Apte, Udayan
通讯作者：
Apte, Udayan
影响因子：
6
作者：
Bhushan, Bharat;Borude, Prachi;Apte, Udayan
通讯作者：
Apte, Udayan