Individual differences in cognitive reappraisal use and emotion regulatory brain function in combat-exposed veterans with and without PTSD.
Individual differences in cognitive reappraisal use and emotion regulatory brain function in combat-exposed veterans with and without PTSD.
复制标题
具有和没有PTSD的战斗暴露的退伍军人的认知重新评估使用和情绪调节大脑功能的个体差异。
DOI：
10.1002/da.22551
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发表时间：
2017-01
影响因子：
7.4
通讯作者：
Phan KL
中科院分区：
文献类型：
--
作者：
Fitzgerald JM;MacNamara A;Kennedy AE;Rabinak CA;Rauch SA;Liberzon I;Phan KL
患有创伤后应激障碍（PTSD）的退伍军人在情绪调节方面表现出明显的缺陷。过去的研究表明，创伤后应激障碍患者在调节负面情绪时，前额皮质参与不足，但无法找到杏仁核下调受损的证据。一种可能性是杏仁核反应性存在变异性，这种变异性会影响诊断状态，并且可以使用个体差异的连续测量来表征。在健康/未受创伤的志愿者中，情绪处理和调节过程中杏仁核参与的个体差异已被证明与调节策略的习惯使用有关。目前的研究调查了患有（n = 28）和没有 PTSD（暴露于战斗的对照，CEC；n = 20）的经历过战斗的退伍军人在认知重新评估期间自我报告的认知重新评估和表达抑制调节策略的使用是否与大脑激活相关。结果表明，无论 PTSD 诊断如何，自我报告更多地使用认知重新评估与在有意识地尝试使用重新评估减轻负面影响时右侧杏仁核的激活较少相关。这一发现与之前的工作一致，并将情绪调节过程中习惯使用调节策略与杏仁核参与之间关联的证据扩展到患有和不患有 PTSD 的创伤暴露样本。此外，通过提供创伤样本中与调节相关的杏仁核反应的个体差异的证据，这一结果可能会增加对支持在 PTSD 个体中观察到的症状表现变异性的神经机制的理解。
Veterans with posttraumatic stress disorder (PTSD) exhibit marked deficits in emotion regulation. Past research has demonstrated under-engagement of the prefrontal cortex during regulation of negative affect in those with PTSD, but has been unable to find evidence of impaired down-regulation of the amygdala. One possibility is that there exists variability in amygdala reactivity that cuts across diagnostic status and which can be characterized using a continuous measure of individual differences. In healthy/non-traumatized volunteers, individual variability in amygdala engagement during emotion processing and regulation has been shown to relate to habitual use of regulation strategies. The current study examined whether self-reported use of cognitive reappraisal and expressive suppression regulation strategies correlated with brain activation during cognitive reappraisal in combat-exposed veterans with (n = 28) and without PTSD (combat-exposed controls, CEC; n = 20). Results showed that greater self-reported use of cognitive reappraisal was associated with less activation in the right amygdala during volitional attempts to attenuate negative affect using reappraisal, irrespective of PTSD diagnosis. This finding is in line with prior work and extends evidence of an association between habitual use of regulation strategies and amygdala engagement during emotion regulation to a trauma-exposed sample of individuals both with and without PTSD. Furthermore, by providing evidence of individual differences in regulation-related amygdala response in a traumatized sample, this result may increase understanding of the neural mechanisms that support variability in symptom manifestation observed across individuals with PTSD.