Probabilistic mapping of deep brain stimulation in childhood dystonia.
Probabilistic mapping of deep brain stimulation in childhood dystonia.
复制标题
儿童肌张力障碍的深部脑刺激的概率图。
DOI：
10.1016/j.parkreldis.2022.11.006
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发表时间：
2022
影响因子：
4.1
通讯作者：
Lumsden DE
中科院分区：
文献类型：
--
作者：
Lumsden DE
目的在成人肌张力障碍患者中，概率刺激标测（PSM）已确定了刺激的假定“最佳点”。我们的目的是将PSM应用到一个队列的儿童和年轻人（ESTA）DBS surgery. MethodsPreoperative MRI和术后CT图像共注册52 ESTA接受双边苍白球DBS（n = 31遗传性/特发性肌张力障碍，n = 21脑瘫（CP））。自动检测DBS电极（n = 104），并根据个体患者刺激设置得出组织激活（VTA）阈值。VTA标准化的MNI 105空间，加权的百分比改善Burke-Fahn-Marsden肌张力障碍评级量表（BFMDRS）在术后一年，平均改善计算为每个voxel.ResultsFor遗传性/特发性肌张力障碍组，BFMDRS改善与刺激跨广泛的体积的GPi。体素的上25百分位数的空间聚类对应于后腹外侧GPi内的更清晰的体积。该体积质心的MNI坐标（X = −23.0，Y = −10.5和Z = −3.5）位于电极放置的典型目标的后上方和上级。VTA体积与先前发表的“甜蜜点”重叠，与手术后的改善相关。相比之下，有最小的BFMDRS改善CP组，没有空间聚类的有效集群和建立的“甜蜜点”之间的相关性不能建立counted.ConclusionsPSM的遗传性/特发性肌张力障碍的patient表明存在一个“甜蜜点”内的GPi电极放置，与以前的研究一致。需要进一步的工作来确定和验证不同患者队列中假定的“甜蜜点”。
ObjectivesIn adults with dystonia Probabilistic Stimulation Mapping (PSM) has identified putative “sweet spots” for stimulation. We aimed to apply PSM to a cohort of Children and Young People (CYP) following DBS surgery.MethodsPre-operative MRI and post-operative CT images were co-registered for 52 CYP undergoing bilateral pallidal DBS (n = 31 genetic/idiopathic dystonia, and n = 21 Cerebral Palsy (CP)). DBS electrodes (n = 104) were automatically detected, and Volumes of Tissue Activation (VTA) derived from individual patient stimulation settings. VTAs were normalised to the MNI105 space, weighted by percentage improvement in Burke-Fahn-Marsden Dystonia Rating scale (BFMDRS) at one-year post surgery and mean improvement was calculated for each voxel.ResultsFor the genetic/idiopathic dystonia group, BFMDRS improvement was associated with stimulation across a broad volume of the GPi. A spatial clustering of the upper 25th percentile of voxels corresponded with a more delineated volume within the posterior ventrolateral GPi. The MNI coordinates of the centroid of this volume (X = −23.0, Y = −10.5 and Z = −3.5) were posterior and superior to the typical target for electrode placement. Volume of VTA overlap with a previously published “sweet spots” correlated with improvement following surgery. In contrast, there was minimal BFMDRS improvement for the CP group, no spatial clustering of efficacious clusters and a correlation between established “sweet spots” could not be established.ConclusionsPSM in CYP with genetic/idiopathic dystonia suggests the presence of a “sweet spot” for electrode placement within the GPi, consistent with previous studies. Further work is required to identify and validate putative “sweet spots” across different cohorts of patients.
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影响因子：
8.6
作者：
Albanese, Alberto;Bhatia, Kailash;Bressman, Susan B.;DeLong, Mahlon R.;Fahn, Stanley;Fung, Victor S. C.;Hallett, Mark;Jankovic, Joseph;Jinnah, Hyder A.;Klein, Christine;Lang, Anthony E.;Mink, Jonathan W.;Teller, Jan K.
通讯作者：
Teller, Jan K.
影响因子：
1.9
作者：
Coblentz, Ailish;Elias, Gavin J. B.;Fasano, Alfonso
通讯作者：
Fasano, Alfonso
DOI：
10.1111/j.1469-8749.2011.04209.x
发表时间：
2012-03-01
影响因子：
3.8
作者：
Monbaliu, Elegast;Ortibus, Els;Feys, Hilde
通讯作者：
Feys, Hilde
影响因子：
11.2
作者：
Horn A;Reich M;Vorwerk J;Li N;Wenzel G;Fang Q;Schmitz-Hübsch T;Nickl R;Kupsch A;Volkmann J;Kühn AA;Fox MD
通讯作者：
Fox MD
DOI：
10.1073/pnas.2114985119
发表时间：
2022-04-05
影响因子：
11.1
作者：
Horn, Andreas;Reich, Martin M.;Ewert, Siobhan;Li, Ningfei;Al-Fatly, Bassam;Lange, Florian;Roothans, Jonas;Oxenford, Simon;Horn, Isabel;Paschen, Steffen;Runge, Joachim;Wodarg, Fritz;Witt, Karsten;Nickl, Robert C.;Wittstock, Matthias;Schneider, Gerd-Helge;Mahlknecht, Philipp;Poewe, Werner;Eisner, Wilhelm;Helmers, Ann-Kristin;Matthies, Cordula;Krauss, Joachim K.;Deuschl, Gunther;Volkmann, Jens;Kuhn, Andrea A.
通讯作者：
Kuhn, Andrea A.