Association of 1-year change in neuroticism and 3-year change in cognitive performance among older depressed adults.
Association of 1-year change in neuroticism and 3-year change in cognitive performance among older depressed adults.
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DOI：
10.1017/s1041610222000084
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发表时间：
2022-07
影响因子：
7
通讯作者：
Grady, James J.
中科院分区：
文献类型：
--
作者：
Steffens, David C.;Manning, Kevin J.;Wu, Rong;Grady, James J.
The relationships among depression, personality factors and cognitive decline in the elderly are complex. Depressed elders score higher in neuroticism than non-depressed older individuals. Presence of neuroticism worsens cognitive decline in depressed older adults. Yet little is known about changes in neuroticism among older adults being treated for depression and the impact of these changes on cognitive decline. Longitudinal observational study. Academic Health Center We examined 68 participants in the Neurobiology of Late-life depression (NBOLD) study to test the hypothesis that older depressed subjects with more improvement in neuroticism would experience less cognitive decline compared with those with less change in neuroticism. Measurements. We measured neuroticism using the NEO-Personality Inventory-Revised at baseline and one year. Study psychiatrists measured depression using the Montgomery-Ǻsberg Depression Rating Scale. Global cognitive performance was measured using the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) battery at baseline and annually over three years. Regression models of one-year change in neuroticism and three-year change in CERAD included sex, age, race, education and one-year change in MADRS score as covariates. We found that among older adults, one-year change in neuroticism was inversely associated with three-year change in CERAD total score. Our findings challenge the notion of longitudinal stability of measures of personality, especially among older depressed individuals. They highlight the importance of repeated personality assessment, especially of neuroticism, in the management of late-life depression. Future studies in larger samples followed for longer periods are needed to confirm our results and to extend them to examine both cognitive change and development of dementia.
