Long-term effects of LCPUFA supplementation on childhood cognitive outcomes
Long-term effects of LCPUFA supplementation on childhood cognitive outcomes
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DOI：
10.3945/ajcn.112.040766
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发表时间：
2013-08-01
影响因子：
7.1
通讯作者：
Brez, Caitlin
中科院分区：
文献类型：
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作者：
Colombo, John;Carlson, Susan E.;Brez, Caitlin
背景：摄入长链多不饱和脂肪酸（LCPUFA）对认知发育的影响存在争议。大多数随机试验评估了18个月时的认知能力，尽管认知能力的显著发展（早期执行功能）出现较晚。目的：目的是评估喂养不同量二十二碳六烯酸的儿童在18个月后的认知能力以及从18个月到6年的纵向认知变化（占总脂肪酸的0.32%、0.64%和0.96%）和花生四烯酸（ARA; 0.64%）与婴儿期未喂食LCPUFA的儿童相比。设计：81个孩子（安慰剂组19例，LCPUFA组62例），婴儿补充LCPUFA的随机试验在18个月时重新入组，每6个月进行一次测试，直到6岁时进行与年龄相适应的标准化和特定认知测试。补充LCPUFA对18个月时的语言和行为标准化测试的表现没有影响;然而，从3到5岁，在规则学习和抑制任务上，在5岁时的皮博迪图片词汇测试，和6岁时的Weschler小学学龄前智力量表。LCPUFAs的影响没有发现任务的空间记忆，简单的抑制，或先进的problem solving.Conclusions：从这个相对较小的试验的数据表明，虽然LCPUFAs的影响可能并不总是明显的标准化发展任务在18个月，显着的影响可能会出现以后更具体或细粒度的任务。研究结果表明，营养和认知发展的研究应该在幼儿期继续进行。该母试验在clinicaltrials.gov上注册为NCT 00266825。
Background: The effect of long-chain polyunsaturated fatty acid (LCPUFA) intake on cognitive development is controversial. Most randomized trials have assessed cognition at 18 mo, although significant development of cognitive abilities (early executive function) emerge later.Objective: The objective was to evaluate cognition beyond 18 mo and longitudinal cognitive change from 18 mo to 6 y in children who were fed variable amounts of docosahexaenoic acid (0.32%, 0.64%, and 0.96% of total fatty acids) and arachidonic acid (ARA; 0.64%) compared with children who were not fed LCPUFA as infants.Design: Eighty-one children (19 placebo, 62 LCPUFA) who participated in a double-blind, randomized trial of LCPUFA supplementation as infants were re-enrolled at 18 mo and tested every 6 mo until 6 y on age-appropriate standardized and specific cognitive tests.Results: LCPUFA supplementation did not influence performance on standardized tests of language and performance at 18 mo; however, significant positive effects were observed from 3 to 5 y on rule-learning and inhibition tasks, the Peabody Picture Vocabulary Test at 5 y, and the Weschler Primary Preschool Scales of Intelligence at 6 y. Effects of LCPUFAs were not found on tasks of spatial memory, simple inhibition, or advanced problem solving.Conclusions: The data from this relatively small trial suggest that, although the effects of LCPUFAs may not always be evident on standardized developmental tasks at 18 mo, significant effects may emerge later on more specific or fine-grained tasks. The results imply that studies of nutrition and cognitive development should be powered to continue through early childhood. This parent trial was registered at clinicaltrials.gov as NCT00266825.