The rise and rise of drug delivery
The rise and rise of drug delivery
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DOI：
10.1038/nrd1721
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发表时间：
2005-05-01
影响因子：
120.1
通讯作者：
Abribat, T
中科院分区：
文献类型：
--
作者：
Rosen, H;Abribat, T
给药通常侧重于优化上市化合物，提高它们的有效性或耐受性，并简化它们的给药。这一角色现在包括第一批生物制药以及更多的常规药物。然而，随着药物输送技术在开发周期的较早阶段发挥作用，它们还可以加强对新化合物的筛选和评估，并‘拯救’失败的化合物，如那些低溶解度的化合物。在这篇文章中，我们回顾了新兴的药物输送领域是如何形成的，并描述了未来发现和发展的方法。时间线|药物输送发现的亮点
Drug delivery has typically focused on optimizing marketed compounds, improving their effectiveness or tolerability, and simplifying their administration. This role now includes the first biopharmaceuticals as well as more conventional drugs. As drug-delivery technologies come into play earlier in the development cycle, however, they can also enhance the screening and evaluation of new compounds and 'rescue' failed compounds, such as those with low solubility. In this article, we look back at how the burgeoning field of drug delivery came into being and describe approaches for future discovery and development.Timeline | Highlights of drug delivery discovery