Contribution of Vaccine-Induced Immunity toward either the HA or the NA Component of Influenza Viruses Limits Secondary Bacterial Complications
Contribution of Vaccine-Induced Immunity toward either the HA or the NA Component of Influenza Viruses Limits Secondary Bacterial Complications
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DOI：
10.1128/jvi.02621-09
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发表时间：
2010-04-01
影响因子：
5.4
通讯作者：
McCullers, Jonathan A.
中科院分区：
文献类型：
--
作者：
Huber, Victor C.;Peltola, Ville;McCullers, Jonathan A.
继发性细菌感染导致流感的发病率和死亡率。疫苗有效性通常以预防流感而不是继发性感染为终点进行评估。我们用含有不同HA和NA蛋白的福尔马林灭活流感病毒疫苗制剂接种小鼠，并证明了诱导适当的抗HA和抗NA免疫谱的能力。针对HA或NA的疫苗诱导的免疫证明了对原发性病毒和继发性细菌感染的保护。这一发现表明，对病毒粒子的NA组分的免疫是可取的，并应考虑在流感疫苗的产生。
Secondary bacterial infections contribute to morbidity and mortality from influenza. Vaccine effectiveness is typically assessed using prevention of influenza, not secondary infections, as an endpoint. We vaccinated mice with formalin-inactivated influenza virus vaccine preparations containing disparate HA and NA proteins and demonstrated an ability to induce the appropriate anti-HA and anti-NA immune profiles. Protection from both primary viral and secondary bacterial infection was demonstrated with vaccine-induced immunity directed toward either the HA or the NA. This finding suggests that immunity toward the NA component of the virion is desirable and should be considered in generation of influenza vaccines.