XBP1 promotes tumor invasion and is associated with poor prognosis in oral squamous cell carcinoma
XBP1 promotes tumor invasion and is associated with poor prognosis in oral squamous cell carcinoma
复制标题
XBP1促进肿瘤侵袭并与口腔鳞状细胞癌的不良预后相关
DOI：
10.3892/or.2018.6498
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发表时间：
2018-08-01
期刊：
影响因子：
4.2
通讯作者：
Zhang, Jiali
中科院分区：
文献类型：
--
作者：
Sun, Yanan;Jiang, Fangyan;Zhang, Jiali
X-box-binding protein 1（X-box-binding protein 1，XBP 1）是一种与乳腺癌、膀胱癌和食管鳞状细胞癌等多种癌症相关的蛋白质。该研究的目的是检查XBP 1在口腔鳞状细胞癌（OSCC）中的转移作用，并确定可能的下游分子。采用免疫组化方法检测96例口腔鳞癌组织芯片中XBP 1的表达水平，分析其与口腔鳞癌转移、临床病理特征及生存预后的关系。与癌旁正常组织相比，在癌中心、癌前区及淋巴结转移灶中，XBP 1的表达明显增强（P
X-box-binding protein 1 (XBP1) contributes to various types of cancer including breast, bladder cancer and esophageal squamous cell carcinoma. The aim of the study was to examine the metastatic role of XBP1 in oral squamous cell carcinoma (OSCC), and identify possible downstream molecules. Immunohistochemical staining was conducted on tissue microarrays comprising 96 OSCC cases to determine the expression level of XBP1 and analyze its association with metastasis, clinicopathological characteristics and survival prognosis. Compared with the adjacent normal tissues of OSCC, the expression of XBP1 was significantly increased in the tumor center and front area, and lymph nodes metastases (P