Individual differences in the attribution of incentive salience to a reward-related cue: Influence on cocaine sensitization
Individual differences in the attribution of incentive salience to a reward-related cue: Influence on cocaine sensitization
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DOI：
10.1016/j.bbr.2007.07.022
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发表时间：
2008-01-10
影响因子：
2.7
通讯作者：
Robinson, Terry E.
中科院分区：
文献类型：
--
作者：
Flagel, Shelly B.;Watson, Stanley J.;Robinson, Terry E.
当一个离散的线索（一个“符号”）在预期食物奖励的过程中被反复呈现时，这个线索会变得充满激励性的显著性，导致一些动物接近并参与其中，这种现象被称为“符号追踪”（动物是符号追踪者; ST）。相比之下，其他动物不会接近提示，而是在提示呈现时前往食物将被递送的位置（目标）。这些动物被称为目标追踪者（GT）。有人假设，那些将过度激励显著性归因于奖励相关线索的人可能特别容易发展成强迫性行为障碍，包括成瘾。因此，我们很感兴趣的是，符号追踪倾向的个体差异是否与可卡因反应性的差异有关。使用一个自动成形程序，其中杠杆（条件刺激）介绍后，立即响应在依赖性交付的食物颗粒（无条件刺激），大鼠首先被定性为ST或GT，随后研究了急性精神反应可卡因和可卡因诱导的精神敏化的倾向。我们发现GT比ST对可卡因的急性运动激活作用更敏感，但ST在重复治疗后表现出更大的精神致敏倾向。这些数据表明，个体差异的倾向，属性奖励显着性离散奖励相关的线索，并接近和从事它，与可卡因诱导的可塑性，可能有助于成瘾的发展形式的易感性。(c)2007 Elsevier B. V.保留所有权利。
When a discrete cue (a "sign") is presented repeatedly in anticipation of a food reward the cue can become imbued with incentive salience, leading some animals to approach and engage it. a phenomenon known as "sign-tracking" (the animals are sign-trackers; STs). In contrast, other animals do not approach the cue, but upon cue presentation go to the location where food will be delivered (the goal). These animals are known as goal-trackers (GTs). It has been hypothesized that individuals who attribute excessive incentive salience to reward-related cues may be especially vulnerable to develop compulsive behavioral disorders, including addiction. We were interested, therefore, in whether individual differences in the propensity to sign-track are associated with differences in responsivity to cocaine. Using an autoshaping procedure in which lever (conditioned stimulus) presentation was immediately followed by the response-in dependent delivery of a food pellet (unconditioned stimulus), rats were first characterized as STs or GTs and subsequently studied for the acute psychomotor response to cocaine and the propensity for cocaine-induced psychomotor sensitization. We found that GTs were more sensitive than STs to the acute locomotor activating effects of cocaine, but STs showed a greater propensity for psychomotor sensitization upon repeated treatment. These data suggest that individual differences in the tendency to attribute incentive salience to a discrete reward-related cue, and to approach and engage it, are associated with susceptibility to a form of cocaine-induced plasticity that may contribute to the development of addiction. (c) 2007 Elsevier B.V. All rights reserved.