Liver transplantation for end-stage alcoholic liver disease: a single-center experience from mainland China
Liver transplantation for end-stage alcoholic liver disease: a single-center experience from mainland China
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肝移植治疗终末期酒精性肝病：中国大陆的单中心经验
DOI：
10.1016/j.alcohol.2010.02.010
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发表时间：
2010-05-01
期刊：
影响因子：
2.3
通讯作者：
Yi, Hui-min
中科院分区：
文献类型：
--
作者：
Chen, Gui-hua;Yang, Yang;Yi, Hui-min
在内地，接受肝移植手术的终末期酒精性肝病患者逐渐增多，中国。然而，很少有研究关注这一人群移植后的结果。这项研究的目的是评估LT对ALD患者的疗效，主要集中在存活率、并发症和酒精复发方面。回顾分析2003年12月至2007年9月在中山大学第三附属医院肝移植中心接受肝移植治疗ALD的20例患者的临床资料。ALD组和非ALD组1、2、3年生存率分别为90.0%、80.0%、80.0%和90.3%、84.7%、79.8%。两组患者的1、2、3年生存率无显著差异(P=.909)。ALD组与非ALD组在术后肺部感染(50.0%比31.9%，P=.137)、胆道并发症(15.0比27.4%，P=.297)、肝动脉并发症(10.0比6.9%，P=.641)、排斥反应(15.0比8.1%，P=.394)等方面差异无统计学意义。只有一个人在LT后恢复了温和的间歇性饮酒。终末期ALD是LT的良好适应证，在非ALD患者中也有类似的结果。肝移植后ALD患者的主要死亡原因为感染性并发症。肝移植术后感染性并发症的预防应引起高度重视。(C)2010 Elsevier Inc.保留所有权利。
There has been a gradual increase in the number of patients with end-stage alcoholic liver disease (ALD) undergoing liver transplantation (LT) in mainland China. However, few studies have focused on the post-transplant outcomes of this population. The aim of this study was to evaluate the efficacy of LT in patients with ALD, mainly focusing on survival rates, complications, and alcohol recidivism. The results were retrospectively analyzed from 20 patients, who underwent LT for ALD from December 2003 to September 2007 at Liver Transplant Center of Third Affiliated Hospital of Sun Yat-sen University. The 1-, 2-, and 3-year survival rates of the ALD group and non-ALD group were 90.0, 80.0, 80.0% and 90.3, 84.7, 79.8%, respectively. There was no significant difference in 1-, 2-, and 3-year survival rates between these two groups (P =.909). No significant difference was observed in complications such as pulmonary infection (50.0 vs. 31.9%, P =.137), biliary complications (15.0 vs. 27.4%, P.297), hepatic arterial complications (10.0 vs. 6.9%, P =.641), and rejection (15.0 vs. 8.1%, P =.394) after LT between the ALD group and non-ALD group. There was only one person who resumed mild, intermittent drinking after LT. End-stage ALD is a good indication for LT, with similar results in non-ALD patients. The major cause of death in ALD patients after LT was infectious complications. More attention is needed for the prophylaxis of infectious complications after LT. (C) 2010 Elsevier Inc. All rights reserved.