Long-term survival outcomes of esophageal cancer after minimally invasive Ivor Lewis esophagectomy.
Long-term survival outcomes of esophageal cancer after minimally invasive Ivor Lewis esophagectomy.
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DOI：
10.1186/s12957-022-02518-0
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发表时间：
2022-02-25
影响因子：
3.2
通讯作者：
Awad ZT
中科院分区：
文献类型：
--
作者：
Pather K;Mobley EM;Guerrier C;Esma R;Kendall H;Awad ZT
The aim of this study was to determine the long-term overall and disease-free survival and factors associated with overall survival in patients with esophageal cancer undergoing a totally minimally invasive Ivor Lewis esophagectomy (MILE) at a safety-net hospital. This was a single-center retrospective review of consecutive patients who underwent MILE from September 2013 to November 2017. Overall and disease-free survival were analyzed by Kaplan-Meier estimates, and hazard ratios (HR) were derived from multivariable Cox regression models. Ninety-six patients underwent MILE during the study period. Overall survival at 1, 3, and 5 years was 83.2%, 61.9%, and 55.9%, respectively. Disease-free survival at 1, 3, and 5 years was 83.2%, 60.6%, and 47.5%, respectively. Overall survival (p < 0.001) and disease-free survival (p < 0.001) differed across pathological stages. By multivariable analysis, increasing age (HR, 1.06; p = 0.02), decreasing Karnofsky performance status score (HR, 0.94; p = 0.002), presence of stage IV disease (HR, 5.62; p = 0.002), locoregional recurrence (HR, 2.94; p = 0.03), and distant recurrence (HR, 4.78; p < 0.001) were negatively associated with overall survival. Overall survival significantly declined within 2 years and was independently associated with stage IV disease (HR, 3.29; p = 0.04) and distant recurrence (HR, 5.78; p < 0.001). MILE offers favorable long-term overall and disease-free survival outcomes. Age, Karnofsky performance status score, stage IV, and disease recurrence are shown to be prognostic factors of overall survival. Prospective studies comparing long-term outcomes after different MIE approaches are warranted to validate survival outcomes after MILE. The online version contains supplementary material available at 10.1186/s12957-022-02518-0.
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影响因子：
9
作者：
Straatman, Jennifer;van der Wielen, Nicole;van der Peet, Donald L.
通讯作者：
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影响因子：
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