The 2013 International Society for Heart and Lung Transplantation Working Formulation for the standardization of nomenclature in the pathologic diagnosis of antibody-mediated rejection in heart transplantation
The 2013 International Society for Heart and Lung Transplantation Working Formulation for the standardization of nomenclature in the pathologic diagnosis of antibody-mediated rejection in heart transplantation
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DOI：
10.1016/j.healun.2013.08.011
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发表时间：
2013-12-01
影响因子：
8.9
通讯作者：
Angelini, Anna Lisa
中科院分区：
文献类型：
--
作者：
Berry, Gerald J.;Burke, Margaret M.;Angelini, Anna Lisa
在过去的25年里，抗体介导的同种异体心脏移植排斥反应已经从一个相对鲜为人知的概念演变为心脏移植患者治疗中公认的临床并发症。在此，我们报告了2010-2012年间举行的一系列会议的共识结果，以制定心脏抗体介导的排斥反应的病理诊断、分级和报告的工作公式。对其形态和免疫病理成分的诊断标准进行了详细列举、说明和描述。许多挑战和尚未解决的临床、免疫学和病理学问题仍然存在，有效的配方可能有助于答案。(C)2013年国际心肺移植学会。版权所有。
During the last 25 years, antibody-mediated rejection of the cardiac allograft has evolved from a relatively obscure concept to a recognized clinical complication in the management of heart transplant patients. Herein we report the consensus findings from a series of meetings held between 2010-2012 to develop a Working Formulation for the pathologic diagnosis, grading, and reporting of cardiac antibody-mediated rejection. The diagnostic criteria for its morphologic and immunopathologic components are enumerated, illustrated, and described in detail. Numerous challenges and unresolved clinical, immunologic, and pathologic questions remain to which a Working Formulation may facilitate answers. (C) 2013 International Society for Heart and Lung Transplantation. All rights reserved.