EFFECTS OF NORMOTHERMIC VERSUS MILD HYPERTHERMIC FOREBRAIN ISCHEMIA IN RATS
EFFECTS OF NORMOTHERMIC VERSUS MILD HYPERTHERMIC FOREBRAIN ISCHEMIA IN RATS
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DOI：
10.1161/01.str.21.9.1318
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发表时间：
1990-09-01
期刊：
影响因子：
8.3
通讯作者：
LOOR, Y
中科院分区：
文献类型：
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作者：
DIETRICH, WD;BUSTO, R;LOOR, Y
我们比较了常温和轻度高温下全前脑缺血的神经病理学后果。21只大鼠进行20分钟的四血管闭塞，在此期间，脑温度保持在37 ℃。C（正常体温，n = 9）或39 ℃。C组（体温过高，n = 12）。1或3天后进行定量神经生理学评估。在缺血损伤后1天，常温大鼠表现出神经元损伤主要局限于最背外侧纹状体。到第3天，缺血细胞存在于整个纹状体和CA1海马在常温动物。与常温对照组相比，脑缺血后1天热疗组大鼠脑损伤的范围和严重程度明显增加。严重神经元坏死和明显梗死的区域包括大脑皮质、CA 1海马、纹状体和丘脑。在小脑和黑质网状部也检测到形态学损伤。在热缺血组中，3天的总死亡率为83%。我们的结论是：（1）与正常体温相比，缺血性热疗明显增加缺血性脑损伤和死亡率，（2）将缺血性细胞损伤转化为明显的梗死，（3）在通常表现为迟发性神经元坏死的区域，加速缺血性脑损伤的形态学表现。这些关于轻度高温的观察结果可能对接受心脏或脑血管手术的患者以及心脏骤停或进展中卒中的患者具有重要意义。
We compared the neuropathological consequences of global forebrain ischemia under normothermia versus mild hyperthermia. Twenty-one rats underwent 20 minutes of four-vessel occlusion during which brain temperature was maintained at either 37.degree. C (normothermia, n = 9) or 39.degree. C (hyperthermia, n = 12). Quantitative neurophysiological assessment was conducted 1 or 3 days later. At 1 day following the ischemic insult, normothermic rats demonstrated neuronal injury mainly confined to the most dorsolateral striatum. By 3 days, ischemic cells were present throughout the striatum and CA1 hippocampus in normothermic animals. Compared with normothermic rats, intraischemic hyperthermia significantly increased the extent and severity of brain damage at 1 day after the ischemic insult. Areas of severe neuronal necrosis and frank infarction included the cerebral cortex, CA1 hippocampus, striatum, and thalamus. Morphologic damage was also detected in the cerebellum and pars reticulata of the substantia nigra. An overall mortality rate of 83% was demonstrated at 3 days in the hyperthermic ischemic group. We conclude that intraischemic hyperthermia (1) markedly augments ischemic brain damage and mortality compared with normothermia, (2) transforms ischemic cell injury into frank infarction, and (3) accelerates the morphological appearance of ischemic brain injury in regions usually demonstrating delayed neuronal necrosis. These observations on mild hyperthermia may have important implications for patients undergoing cardiac or cerebrovascular surgery as well as patients following cardiac arrest or those with stroke-in-evolution.