Serum Cholesterol Efflux Capacity in Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy.
Serum Cholesterol Efflux Capacity in Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy.
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DOI：
10.1016/j.xops.2022.100142
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发表时间：
2022-06
影响因子：
--
通讯作者：
Cheung, Chui Ming Gemmy
中科院分区：
文献类型：
--
作者：
Yanagi, Yasuo;Yu, Richard M. C.;Ahamed, Waseem;Yu, Marco;Teo, Kelvin Yi Chong;Tan, Anna C. S.;Cheng, Ching-Yu;Wong, Tien Yin;Apte, Rajendra S.;Cheung, Chui Ming Gemmy
使用核磁共振定量测量年龄相关性黄斑变性 (AMD) 患者的脂蛋白颗粒组成和大小以及载脂蛋白指标，研究血清胆固醇流出能力（血清接受胆固醇的能力）及其调节因素。病例对照研究。 402 份血清样本来自 80 名早期 AMD (eAMD) 患者和 212 名新生血管性 AMD (nAMD) 患者，其中包括 80 名典型 nAMD (tAMD) 和 132 名息肉状脉络膜血管病变 (PCV) 患者，以及 110 名年龄和性别匹配的对照参与者。参与者的血清显示了使用体外细胞测定测量的胆固醇流出能力和使用核磁共振（南丁格尔有限公司）测量的脂蛋白亚组分。在患者和对照参与者中研究了胆固醇流出能力（以百分比测量）和脂质亚组分之间的关联。对照、eAMD 和 nAMD 中的胆固醇流出能力和脂质亚组分。 HDL 亚组分与胆固醇流出能力之间的关联。调整年龄、性别和降脂药物使用后，eAMD（68.0±11.3%[平均值±标准差]）和nAMD（75.9±27.7%）患者的胆固醇流出能力高于对照参与者（56.9±16.7%）（P<0.0001）。核磁共振脂质组学表明，与对照组参与者相比，eAMD（9.96±0.27毫米[平均值±标准差]）和PCV（9.97±0.23毫米）的HDL平均直径更大（9.84±0.24毫米；两者P = 0.0001）。在 28 个 HDL 亚组分中，大多数小、中和大 HDL，但 7 个超大 HDL 组分均与 eAMD 和 PCV 中的胆固醇流出能力中度相关（R = 0.149–0.277）。 eAMD 和 PCV 中的血清胆固醇流出能力增加，但 tAMD 没有增加，这可能反映了 tAMD 和 PCV 中脂质失调的潜在病理生理学特征的差异。进一步的研究应致力于研究 HDL 在 AMD 中的多种生物活性，包括黄斑色素转运、炎症调节和局部胆固醇转运系统。
To investigate serum cholesterol efflux capacity (the ability of the serum to accept cholesterol) and factors that regulate it using nuclear magnetic resonance-quantified measures of lipoprotein particle composition and size and apolipoproteins metrics in patients with age-related macular degeneration (AMD). Case-control study. Four hundred two serum samples from 80 patients with early AMD (eAMD), and 212 patients with neovascular AMD (nAMD), including 80 with typical nAMD (tAMD) and 132 with polypoidal choroidal vasculopathy (PCV), and 110 age- and gender matched control participants. Serum from participants showed cholesterol efflux capacity measured using in vitro cell assays and lipoprotein subfractions measured using nuclear magnetic resonance (Nightingale, Ltd). Associations between cholesterol efflux capacity (measured in percentage) and lipid subfractions were investigated in the patients and control participants. Cholesterol efflux capacity and lipid subfractions in control, eAMD, and nAMD. Associations between HDL subfractions and cholesterol efflux capacity. Cholesterol efflux capacity was higher in patients with eAMD (68.0 ± 11.3% [mean ± standard deviation]) and nAMD (75.9 ± 27.7%) than in the control participants (56.9 ± 16.7%) after adjusting for age, gender, and use of lipid-lowering drug (P < 0.0001). Nuclear magnetic resonance lipidomics demonstrated that the mean diameter of HDL was larger both in eAMD (9.96 ± 0.27 mm [mean ± standard deviation]) and PCV (9.97 ± 0.23 mm) compared with that of the control participants (9.84 ± 0.24 mm; P = 0.0001 for both). Among the 28 HDL subfractions, most of the small, medium, and large HDLs, but none of the 7 extra large HDLs fractions, were associated moderately with cholesterol efflux capacity in eAMD and PCV (R = 0.149–0.277). Serum cholesterol efflux capacity was increased in eAMD and PCV, but not tAMD, possibly reflecting differential underlying pathophysiologic features of lipid dysregulation in tAMD and PCV. Further studies should be directed toward investigating the diverse biological activities of HDL in AMD, including macular pigment transport, regulation of inflammation, and local cholesterol transport system.
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影响因子：
16.6
作者：
Cheng, Ching-Yu;Yamashiro, Kenji;Chen, Li Jia;Ahn, Jeeyun;Huang, Lulin;Huang, Lvzhen;Cheung, Chui Ming G.;Miyake, Masahiro;Cackett, Peter D.;Yeo, Ian Y.;Laude, Augustinus;Mathur, Ranjana;Pang, Junxiong;Sim, Kar Seng;Koh, Adrian H.;Chen, Peng;Lee, Shu Yen;Wong, Doric;Chan, Choi Mun;Loh, Boon Kwang;Sun, Yaoyao;Davila, Sonia;Nakata, Isao;Nakanishi, Hideo;Akagi-Kurashige, Yumiko;Gotoh, Norimoto;Tsujikawa, Akitaka;Matsuda, Fumihiko;Mori, Keisuke;Yoneya, Shin;Sakurada, Yoichi;Iijima, Hiroyuki;Iida, Tomohiro;Honda, Shigeru;Lai, Timothy Yuk Yau;Tam, Pancy Oi Sin;Chen, Haoyu;Tang, Shibo;Ding, Xiaoyan;Wen, Feng;Lu, Fang;Zhang, Xiongze;Shi, Yi;Zhao, Peiquan;Zhao, Bowen;Sang, Jinghong;Gong, Bo;Dorajoo, Rajkumar;Yuan, Jian-Min;Koh, Woon-Puay;van Dam, Rob M.;Friedlander, Yechiel;Lin, Ying;Hibberd, Martin L.;Foo, Jia Nee;Wang, Ningli;Wong, Chang Hua;Tan, Gavin S.;Park, Sang Jun;Bhargava, Mayuri;Gopal, Lingam;Naing, Thet;Liao, Jiemin;Ong, Peng Guan;Mitchell, Paul;Zhou, Peng;Xie, Xuefeng;Liang, Jinlong;Mei, Junpu;Jin, Xin;Saw, Seang-Mei;Ozaki, Mineo;Mizoguchi, Takanori;Kurimoto, Yasuo;Woo, Se Joon;Chung, Hum;Yu, Hyeong-Gon;Shin, Joo Young;Park, Dong Ho;Kim, In Taek;Chang, Woohyok;Sagong, Min;Lee, Sang-Joon;Kim, Hyun Woong;Lee, Ji Eun;Li, Yi;Liu, Jianjun;Teo, Yik Ying;Heng, Chew Kiat;Lim, Tock Han;Yang, Suk-Kyun;Song, Kyuyoung;Vithana, Eranga N.;Aung, Tin;Bei, Jin Xin;Zeng, Yi Xin;Tai, E. Shyong;Li, Xiao Xin;Yang, Zhenglin;Park, Kyu-Hyung;Pang, Chi Pui;Yoshimura, Nagahisa;Wong, Tien Yin;Khor, Chiea Chuen
通讯作者：
Khor, Chiea Chuen
影响因子：
3.7
作者：
Guymer, Robyn H.;Baird, Paul N.;Robman, Liubov D.
通讯作者：
Robman, Liubov D.
DOI：
10.1161/atvbaha.113.301373
发表时间：
2013-07
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Li XM;Tang WH;Mosior MK;Huang Y;Wu Y;Matter W;Gao V;Schmitt D;Didonato JA;Fisher EA;Smith JD;Hazen SL
通讯作者：
Hazen SL
影响因子：
4.4
作者：
Curcio CA
通讯作者：
Curcio CA
影响因子：
4.4
作者：
Curcio CA
通讯作者：
Curcio CA