Possible involvement of prolactin in the synthesis of lactoferrin in bovine mammary epithelial cells
Possible involvement of prolactin in the synthesis of lactoferrin in bovine mammary epithelial cells
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DOI：
10.1271/bbb.70713
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发表时间：
2008-04-01
影响因子：
1.6
通讯作者：
Kozakai, Takaharu
中科院分区：
文献类型：
--
作者：
Nakajima, Kei-ichi;Nakamura, Masato;Kozakai, Takaharu
牛乳腺上皮细胞（bMEC）合成乳铁蛋白，并分泌到乳汁中。我们的结果表明，在无血清条件下，催乳素刺激原代 bMEC 及其克隆细胞系中乳铁蛋白的分泌。催乳素还刺激克隆细胞系中乳铁蛋白的 mRNA 表达。 AG-490 可减弱这种效应，表明催乳素刺激的乳铁蛋白 mRNA 表达是由 Janus 激酶 (JAK)2 介导的。
Bovine mammary epithelial cells (bMECs) synthesize lactoferrin, which is secreted into milk. Our results suggest that prolactin stimulated secretion of lactoferrin in primary bMECs and their clonal cell line under serum-free conditions. Prolactin also stimulated mRNA expression of lactoferrin in the clonal cell line. This effect was reduced by AG-490, suggesting that the prolactin-stimulated mRNA expression of lactoferrin was mediated by Janus kinase (JAK)2.