Development and Physiological Regulation of Intestinal Lipid Absorption. II. Dietary lipid absorption, complex lipid synthesis, and the intracellular packaging and secretion of chylomicrons
Development and Physiological Regulation of Intestinal Lipid Absorption. II. Dietary lipid absorption, complex lipid synthesis, and the intracellular packaging and secretion of chylomicrons
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DOI：
10.1152/ajpgi.00299.2007
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发表时间：
2007-10-01
影响因子：
4.5
通讯作者：
Gorelick, Fred
中科院分区：
文献类型：
--
作者：
Mansbach, Charles M., II;Gorelick, Fred
肠道脂肪吸收的发展及其生理调节。饲料中脂肪的吸收、复合脂肪的合成，以及乳糜粒的细胞内包装和分泌。Am J Physiol胃肠病肝生理学293：G645-G650,2007。2007年7月12日首次出版；doi：10.1152/ajpgi.00299.2007。-由于肥胖症在美国的广泛流行，饮食脂肪吸收的研究变得迫切。尽管它在临床上具有重要的意义，但对于这一过程的一些基本方面，从脂肪酸摄取的机制到乳糜粒中三酰甘油输出的控制，仍存在许多争议。最近的进展包括一些脂肪酸转运体的鉴定，酰基辅酶A合成酶长链和酰基转移酶家族的发现，肝脏脂肪酸结合蛋白的生理功能，以及将乳糜粒从内质网运输到高尔基体的前乳糜粒转运囊的特征。
Development and Physiological Regulation of Intestinal Lipid Absorption. III. Dietary lipid absorption, complex lipid synthesis, and the intracellular packaging and secretion of chylomicrons. Am J Physiol Gastrointest Liver Physiol 293: G645-G650, 2007. First published July 12, 2007; doi: 10.1152/ajpgi.00299.2007. -Research in dietary fat absorption has developed urgency because of the widely recognized epidemic of obesity in the United States. Despite its clinical importance, many controversies exist over some of the basic aspects of this process from the mechanisms of fatty acid uptake to the control of triacylglycerol export in chylomicrons. Recent advances have included the identification of a number of fatty acid transporters, the discovery of families of acyl-CoA synthetase long chains and acyltransferases, a physiological function for liver-fatty acid binding protein, and the characterization of the prechylomicron transport vesicle transporting chylomicrons from the endoplasmic reticulum to the Golgi.