Photoacoustic-guided ultrasound therapy with a dual-mode ultrasound array
Photoacoustic-guided ultrasound therapy with a dual-mode ultrasound array
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DOI：
10.1117/1.jbo.17.6.061205
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发表时间：
2012-06-01
影响因子：
3.5
通讯作者：
Bossy, Emmanuel
中科院分区：
文献类型：
--
作者：
Prost, Amaury;Funke, Arik;Bossy, Emmanuel
光声最近被提出作为一种潜在的方法来引导和/或监测基于高强度聚焦超声（HIFU）的治疗。我们通过实验证明了在光学吸收体的位置处创建HIFU损伤，通过使用在双模换能器阵列上检测到的吸收体发出的光声信号。为此，使用了专用超声阵列，其旨在检测光声波并发射具有相同元件的HIFU。这种双模式阵列为光声检测和HIFU发射提供自动共配准的参考系，这是涉及通过使用光声引导或监测HIFU的方法的高度期望的特征。该原型首先在光声和HIFU性能方面进行了表征。然后，探头用于执行光声引导治疗的理想化场景，其中由嵌入一块鸡胸肉中的吸收线产生的光声信号用于利用时间反转镜自动重新聚焦HIFU光束，并使吸收器位置处的组织坏死。(C)2012年，美国光电仪器工程师学会（SPIE）。[DOI：10.1117/1.JBO.17.6.061205]
Photoacoustics has recently been proposed as a potential method to guide and/or monitor therapy based on high-intensity focused ultrasound (HIFU). We experimentally demonstrate the creation of a HIFU lesion at the location of an optical absorber, by use of photoacoustic signals emitted by the absorber detected on a dual mode transducer array. To do so, a dedicated ultrasound array intended to both detect photoacoustic waves and emit HIFU with the same elements was used. Such a dual-mode array provides automatically coregistered reference frames for photoacoustic detection and HIFU emission, a highly desired feature for methods involving guidance or monitoring of HIFU by use of photoacoustics. The prototype is first characterized in terms of both photoacoustic and HIFU performances. The probe is then used to perform an idealized scenario of photoacoustic-guided therapy, where photoacoustic signals generated by an absorbing thread embedded in a piece of chicken breast are used to automatically refocus a HIFU beam with a time-reversal mirror and necrose the tissue at the location of the absorber. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JBO.17.6.061205]