NINDS stroke genetics network (SiGN) experience with the causative classification system.
NINDS stroke genetics network (SiGN) experience with the causative classification system.
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NINDS 中风遗传学网络 (SiGN) 在病因分类系统方面的经验。
DOI：
10.1111/j.1747-4949.2012.00944.x
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Kittner,StevenJ
中科院分区：
文献类型：
--
作者：
Meschia,JamesF;Worrall,BradfordB;Brown,RobertD;Ay,Hakan;McArdle,PatrickF;Rundek,Tatjana;Kittner,StevenJ
Lanfranconi 和 Markus (1) 最近描述了在 Wellcome Trust Case Control Consortium-2 中进行基因分型的病例中使用病因分类系统 (CCS) 的单中心经验，并报告了与 TOAST 亚型分型的高一致率。他们的结论是，基于网络的 CCS 似乎适合多中心研究。我们想概述一下 NINDS 资助的中风遗传学网络 (SiGN) 使用 CCS 的持续经验。截至 2012 年 3 月 10 日，医师评审员已在 SiGN 中对 15 252 例病例进行了分类，其中 11 021 例目前在数据库中具有 TOAST 亚型。所有案件均使用特定于研究的 CCS 版本进行裁决，该版本已稍作修改以促进研究协调 (2)。每位评审员都经过在线教育模块的培训和认证。 SiGN 目前在 10 个国家的 21 个中心拥有 53 名经过认证的评审员，其中包括伦敦圣乔治医院。在规划 SiGN 时，研究人员考虑了由委员会进行的中央裁决，类似于缺血性中风遗传学研究 (ISGS)(3) 中的做法。最终，采用了分散的子类型方法，因为它被认为具有时间效率，并且有更多的裁决者并行操作。对于病历为英文的中心，SiGN 表型委员会通过对随机病例样本进行集中重新裁决来提供质量控制。对于医疗记录采用英语以外语言的中心，表型委员会向中心提供随机选择的病例清单，供当地 CCS 认证医生重新裁决。
Lanfranconi and Markus (1) recently described a single-center experience using the Causative Classification System (CCS) in cases genotyped in the Wellcome Trust Case Control Consortium-2 and report high agreement rates with TOAST subtyping. They conclude that the web-based CCS appears suitable for multicenter studies. We would like to outline the ongoing NINDS-funded Stroke Genetics Network (SiGN) experience using the CCS. As of March 10, 2012, physician adjudicators have classified 15 252 cases in SiGN, of which 11 021 currently have TOAST subtyping in the database. All cases were adjudicated using a study-specific version of CCS, which has been slightly modified to facilitate study coordination (2). Every adjudicator has been trained and certified using an online education module. SiGN currently has 53 certified adjudicators across 10 countries at 21 centers, including the St. George’s Hospital, London. When planning SiGN, investigators considered central adjudication by a committee analogous to what was done in the Ischemic Stroke Genetics Study (ISGS)(3). Ultimately, a decentralized approach to subtyping was adopted because it was seen as time efficient, with more adjudicators operating in parallel. For centers where medical records are in English, the SiGN Phenotype Committee provides quality control through central readjudication of a random sample of cases. For centers where medical records are in a language other than English, the Phenotype Committee provides the center with a list of cases selected at random for readjudication by a local CCS-certified physician.