Fluorescent polymer-based post-translational differentiation and subtyping of breast cancer cells.
Fluorescent polymer-based post-translational differentiation and subtyping of breast cancer cells.
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基于荧光聚合物的乳腺癌细胞翻译后分化和亚型分析。
DOI：
10.1039/c2an35877h
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Mallik,Sanku
中科院分区：
文献类型：
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作者：
Scott,MichaelD;Dutta,Rinku;Haldar,ManasK;Wagh,Anil;Gustad,ThomasR;Law,Benedict;Friesner,DanielL;Mallik,Sanku
在此，我们报告了人工合成的荧光、水溶性聚合物在体外对乳腺癌细胞进行翻译后亚型和分化的应用。这些聚合物的荧光发射光谱在不同乳腺癌细胞的条件细胞培养液中被不同地调制。这些聚合物在翻译后水平上发生分化，可能是因为它们能够与在癌症条件下过度表达的胞外酶相互作用。
Herein, we report the application of synthesized fluorescent, water soluble polymers for post-translational subtyping and differentiation of breast cancer cells in vitro. The fluorescence emission spectra from these polymers were modulated differently in the presence of conditioned cell culture media from various breast cancer cells. These polymers differentiate at a post-translation level possibly due to their ability to interact with extracellular enzymes that are over-expressed in cancerous conditions.