Identification and Characterization of a Novel pic Gene Cluster Responsible for Picolinic Acid Degradation in Alcaligenes faecalis JQ135
Identification and Characterization of a Novel pic Gene Cluster Responsible for Picolinic Acid Degradation in Alcaligenes faecalis JQ135
复制标题
粪产碱菌 JQ135 中负责吡啶甲酸降解的新型 pic 基因簇的鉴定和表征
DOI：
10.1128/jb.00077-19
复制
发表时间：
2019-08-01
影响因子：
3.2
通讯作者：
He, Jian
中科院分区：
文献类型：
--
作者：
Qiu, Jiguo;Zhao, Lingling;He, Jian
吡啶甲酸是一种常见的代谢产物，
L
- 色氨酸和一些芳香族化合物，是有机化学合成的重要中间体。尽管吡啶甲酸的微生物降解/解毒已经研究了50多年，但其潜在的分子机制仍然未知。在这里，我们表明，
pic
基因簇负责吡啶甲酸的完全降解。的
pic
基因簇被发现广泛存在于其他
阿尔法
-,
Beta
- ，以及
γ变形
.这些发现为理解吡啶甲酸在细菌中的分解代谢机制提供了新的视角。
Picolinic acid is a common metabolite of
l
-tryptophan and some aromatic compounds and is an important intermediate in organic chemical synthesis. Although the microbial degradation/detoxification of picolinic acid has been studied for over 50 years, the underlying molecular mechanisms are still unknown. Here, we show that the
pic
gene cluster is responsible for the complete degradation of picolinic acid. The
pic
gene cluster was found to be widespread in other
Alpha
-,
Beta
-, and
Gammaproteobacteria
. These findings provide a new perspective for understanding the catabolic mechanisms of picolinic acid in bacteria.