A contribution to genome-wide association studies: search for susceptibility loci for schizophrenia using DNA microsatellite markers on chromosomes 19, 20, 21 and 22
A contribution to genome-wide association studies: search for susceptibility loci for schizophrenia using DNA microsatellite markers on chromosomes 19, 20, 21 and 22
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DOI：
10.1097/00041444-200010030-00006
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发表时间：
2000-09-01
影响因子：
0.9
通讯作者：
Yagi, G
中科院分区：
文献类型：
--
作者：
Kitao, Y;Inada, T;Yagi, G
作为全基因组关联研究的第一步，我们通过病例对照设计寻找精神分裂症与染色体19、20、21和22上34个微卫星标记之间的关联。研究人员对168名精神分裂症患者和146名日本人作为对照进行了相关性研究。34个位点的等位基因分布在日本和法国人群中存在显著差异。在对照组的D19S209和D21S1256处观察到与Hardy-Weinberg平衡的显著偏差。初步筛选的病例对照比较显示，D20S95位点等位基因频率差异显著，D20S118位点有差异趋势。为了证实这些可能的关联，我们对110名精神分裂症患者和116名对照受试者进行了额外的检测，并证实了D20S95与精神分裂症之间的关联（经Bonferroni校正后的校正P值为0.00035）。D20S95位于编码嗜铬粒蛋白b的基因（CHGB）附近，这些发现提示CHGB可能是参与精神分裂症发展的重要候选基因。《精神病学杂志》（英文版），2000。
As an initial step for genome-wide association studies, we sought an association between schizophrenia and 34 microsatellite markers on chromosomes 19, 20, 21 and 22 by a case-control design. The samples examined for an association were 168 schizophrenic patients and 146 control subjects in the Japanese population. The allele distribution of the 34 loci differed significantly between Japanese and French populations. Significant deviation from the Hardy-Weinberg equilibrium was observed at D19S209 and D21S1256 in the control subjects. Case-control comparisons of the initial screening revealed a significant difference in allele frequency at D20S95 and a trend of difference at D20S118. To confirm these possible associations, additional samples consisting of 110 schizophrenic patients and 116 control subjects were examined, and an association between D20S95 and schizophrenia was confirmed (corrected P value after Bonferroni correction, 0.00035). D20S95 is located close to the gene (CHGB) encoding chromogranin B. These findings suggest that CHGB could be an important candidate gene involved in the development of schizophrenia. Psychiatr Genet 10:139-143 (C) 2000 Lippincott Williams & Wilkins.