Comparison of [18F]fluorodeoxyglucose uptake with glucose transporter-1 expression and proliferation rate in human glioma and non-small-cell lung cancer
Comparison of [18F]fluorodeoxyglucose uptake with glucose transporter-1 expression and proliferation rate in human glioma and non-small-cell lung cancer
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DOI：
10.1097/00006231-200401000-00003
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发表时间：
2004-01-01
影响因子：
1.5
通讯作者：
Lee, MC
中科院分区：
文献类型：
--
作者：
Chung, JK;Lee, YJ;Lee, MC
为了阐明[F-18]氟脱氧葡萄糖（F-18-FDG）在癌症患者中蓄积的生物学意义，我们评估了人胶质瘤和肺癌中F-18-FDG摄取与葡萄糖转运蛋白-1（GLUT-1）表达和增殖率之间的关系。我们获得了13例脑胶质瘤患者和25例非小细胞肺癌患者的FDG PET图像，并测量了原发肿瘤的标准化摄取值（SUV）。手术后，获得相关肿瘤的部分，并使用DNA流式细胞术测量增殖率作为增殖指数（（S+G2+M）/（G 0 +G1+S+G2+M）的百分比）。GLUT-1在肿瘤中的表达通过使用免疫染色来评估。我们将GLUT-1表达分为0级（无阳性细胞）、1级（
To clarify the biological significance of [F-18]fluorodeoxyglucose (F-18-FDG) accumulation in patients with cancer, we assessed the relationships between F-18-FDG uptake and glucose transporter-1 (GLUT-1) expression and proliferation rate in human glioma and lung cancer. We obtained FDG PET images and measured standardized uptake values (SUVs) of primary tumours in 13 patients with brain glioma and 25 patients with non-small-cell lung cancer. After surgery, portions of respected tumours were obtained, and the proliferation rate was measured as proliferation index (per cent of (S+G2+M)/(G0+G1+S+G2+M)) using DNA flow cytometry. The expression of GLUT-1 in a tumour was evaluated by using immunostaining. We classified GLUT-1 expression as grade 0 (no positive cell), grade 1 (