Serum soluble interleukin-2 receptor level is a predictive marker for EBUS-TBNA-based diagnosis of sarcoidosis.
Serum soluble interleukin-2 receptor level is a predictive marker for EBUS-TBNA-based diagnosis of sarcoidosis.
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DOI：
10.36141/svdld.v37i1.8313
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Inoue T
中科院分区：
文献类型：
--
作者：
Miyata J;Ogawa T;Tagami Y;Sato T;Nagayama M;Hirano T;Kameyama N;Fukunaga K;Kawana A;Inoue T
经纤维支气管镜下超声引导下经支气管针吸活检术(EBUS-TBNA)是一种广泛应用于疑似I/II期结节病的诊断工具。EBUS-TBNA联合经纤维支气管镜肺活检(TBLB)已被建议作为临床诊断程序。本研究的目的是评估EBUS-TBNA和TBLB的联合诊断效果，并找出与高诊断率相关的标记。我们回顾分析了37例疑似I/II期结节病伴肺门或纵隔淋巴结肿大的CT资料。这些患者原本计划接受EBUS-TBNA和TBLB。血清结节病标志物(血管紧张素转换酶[ACE]、可溶性白介素2受体[sIL-2R]和溶菌酶)水平、CT表现和检查技术被评估为诊断的预测指标。在37例患者中，32例同时接受了EBUS-TBNA和TBLB，其余5例仅接受了EBUS-TBNA。诊断符合率为50.0%(16/32)、83.8%(31/37)和100.0%(16/32)。血清sIL-2R水平与EBUS-TBNA诊断成功相关，而与ACE和溶菌酶水平无关。在I/II期结节病患者中，血清sIL-2R水平是一项有前景的有用指标，可用于预测EBUS-TBNA的诊断，减轻额外的TBLB的负担及其可能的并发症。(结节病血管痉挛弥漫性肺病2020；37(1)：8-16)
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a widely available diagnostic tool for suspected stage I/II sarcoidosis. Combination of EBUS-TBNA and transbronchial lung biopsy (TBLB) has been proposed as diagnostic procedure in clinical settings. The aim of this study was to assess the diagnostic yield of combined EBUS-TBNA and TBLB and identify the markers correlated with a high diagnostic rate. We retrospectively analyzed the data of 37 patients with suspected stage I/II sarcoidosis with enlarged hilar or mediastinal lymph nodes on computed tomography (CT) images. These patients had been scheduled to undergo EBUS-TBNA and TBLB. Serum levels of sarcoidosis markers (angiotensin-converting enzyme [ACE], soluble interleukin-2 receptor [sIL-2R], and lysozyme), CT findings, and examination techniques were evaluated as predictive markers for diagnosis. Of the 37 patients, 32 had undergone both EBUS-TBNA and TBLB, while the remaining 5 patients had only undergone EBUS-TBNA. The diagnosis was confirmed by TBLB in 16 of the 32 patients (50.0%), EBUS-TBNA in 31 of the 37 patients (83.8%), and combined TBLB and EBUS-TBNA in all patients (100.0%). The serum level of sIL-2R, but not that of ACE or lysozyme, was correlated with successful diagnosis by EBUS-TBNA. In patients with stage I/II sarcoidosis, the serum level of sIL-2R is a promising and useful marker for predicting the diagnosis by EBUS-TBNA and reducing the burden of additional TBLB and its possible complications. (Sarcoidosis Vasc Diffuse Lung Dis 2020; 37 (1): 8-16)
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影响因子：
3.1
作者：
Thi Hong Nguyen, Chuyen;Kambe, Naotomo;Okamoto, Hiroyuki
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DOI：
10.20452/pamw.3934
发表时间：
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