Patterns of acute leukaemia occurrence among children in the Chernobyl region.
Patterns of acute leukaemia occurrence among children in the Chernobyl region.
复制标题
切尔诺贝利地区儿童急性白血病的发生模式。
DOI：
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复制
发表时间：
2001
影响因子：
7.7
通讯作者：
A. Michalek
中科院分区：
文献类型：
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作者：
A. Noshchenko;K. Moysich;A. Bondar;P. V. Zamostyan;V. D. Drosdova;A. Michalek
背景
1986年切尔诺贝利核事故释放了大量放射性物质，造成广泛污染。仅在乌克兰，就有400多万人受到辐射。这种接触的确切健康后果仍在评估中。
方法
为了确定子宫内辐射照射的影响和白血病的发展，对事故发生当年（1986年）出生的儿童中发生的白血病亚型进行了审查，并在照射后跟踪了10年。比较了受辐射和未受辐射州儿童的白血病累积发病率。
结果
所有细胞类型白血病的发病率比显示，在受辐射的州，女性、男性和男女合计的发病率显著升高。男性急性淋巴细胞白血病（ALL）的发病率显著升高，女性发病率较低。对于两种性别的组合，ALL的RR在暴露区比未暴露区高三倍以上。
结论
研究结果表明，1986年出生并居住在放射性污染地区的儿童患白血病和急性白血病的风险增加，可能与接触切尔诺贝利事故造成的辐射有关。
BACKGROUND
The Chernobyl nuclear accident of 1986 released large quantities of radioactive material causing widespread contamination. In the Ukraine alone, more than 4 million people were exposed to radiation. The exact health consequences of this exposure are still being assessed.
METHODS
To ascertain the effect of in utero radiation exposure and the development of leukaemia, a review was undertaken of leukaemia sub-types occurring among children born in the year of the accident (1986) and followed 10 years post-exposure. A comparison was made of leukaemia cumulative incidence rates among children from both an exposed and unexposed oblast.
RESULTS
Rate ratios (RR) for the all cell types grouping of leukaemia revealed that rates in the exposed Oblast were significantly elevated for females, males and both genders combined. Rates of acute lymphoblastic leukaemia (ALL) were dramatically elevated for males and to a lesser extent for females. For both genders combined, the RR for ALL was more than three times greater in the exposed compared to the unexposed region.
CONCLUSION
Study results suggest that the increased risk of leukaemia and acute leukaemia among those children born in 1986 and resident in radioactively contaminated territories may be associated with exposure to radiation resulting from the Chernobyl accident.