Analysis of Gut Microbiota in Coronary Artery Disease Patients: a Possible Link between Gut Microbiota and Coronary Artery Disease
Analysis of Gut Microbiota in Coronary Artery Disease Patients: a Possible Link between Gut Microbiota and Coronary Artery Disease
复制标题
DOI：
10.5551/jat.32672
复制
发表时间：
2016-01-01
影响因子：
4.4
通讯作者：
Hirata, Ken-ichi
中科院分区：
文献类型：
--
作者：
Emoto, Takuo;Yamashita, Tomoya;Hirata, Ken-ichi
目的：最近的研究表明，肥胖和2型糖尿病等代谢紊乱与肠道微生物区系有关。动脉粥样硬化和肠道微生物区系之间的联系也引起了越来越多的关注。方法：本研究包括39例冠心病患者、30例年龄和性别匹配的有冠状动脉危险因素的非冠心病对照(CtrlS)和50例无冠状动脉危险因素的健康志愿者(HV)。结果：冠心病患者肠道微生物区系发生了特征性的变化，其中乳杆菌菌群顺序增加(CAD13.6%+/-12.0%，6.2%+/-7.7%vs.4.1%+/-5.9%；p<；0.001)，类杆菌(类杆菌+普氏杆菌)减少(CADCtrlvs.Hv；35.5%+/-11.6%，43.9%+/-11.2%对47.4%+/-11.5%；p<；0.001)。与Ctrl或HV组(P<；0.001，卡方检验)相比，冠心病组在肠型“Other”(III)中的比例过高，尽管我们不能否认某些药物影响肠道菌群类型的可能性。结论：尽管本研究有一定的局限性，但我们证明了冠心病的发生与肠道微生物区系的改变有关。需要一项前瞻性研究来阐明CAD和肠道微生物区系之间的因果关系。
Aim: Recent studies have suggested that metabolic disorders such as obesity and type 2 diabetes are associated with gut microbiota. The association between atherosclerosis and gut microbiota has also been attracting increased attention. Our aim was to specify a characteristic trend of gut microbiota in coronary artery disease (CAD).Methods: This study included 39 CAD patients, 30 age-and sex-matched no-CAD controls (Ctrls) with coronary risk factors and 50 healthy volunteers (HVs) without coronary risk factors. Bacterial DNA was extracted from their fecal samples and analyzed by terminal restriction fragment length polymorphism.Results: A characteristic change of gut microbiota was observed in CAD patients, where the order Lactobacillales was increased (CAD, Ctrl vs. HV; 13.6%+/- 12.0%, 6.2%+/- 7.7% vs. 4.1%+/- 5.9%; p< 0.001) and the phylum Bacteroidetes (Bacteroides+ Prevotella) was decreased (CAD, Ctrl vs. HV; 35.5%+/- 11.6%, 43.9%+/- 11.2% vs. 47.4%+/- 11.5%; p< 0.001). The CAD group was over-represented in enterotype "others" (III), compared with the Ctrl or HV group (p< 0.001, chi-squared test), although we could not deny the possibility that some drugs affect the gut flora types.Conclusions: Although this study had some limitations, we demonstrated that the incidence of CAD was linked with an alteration of gut microbiota. A prospective study is desired to clarify a causal relationship between CAD and gut microbiota.