The neuronal toxicity of sulfite plus peroxynitrite is enhanced by glutathione depletion: Implications for Parkinson's disease
The neuronal toxicity of sulfite plus peroxynitrite is enhanced by glutathione depletion: Implications for Parkinson's disease
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DOI：
10.1016/s0891-5849(99)00094-5
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发表时间：
1999-09-01
影响因子：
7.4
通讯作者：
Halliwell, B
中科院分区：
文献类型：
--
作者：
Marshall, KA;Reist, R;Halliwell, B
在帕金森病（PD）和偶发路易体病中，黑质谷胱甘肽水平降低40-50%。过氧亚硝酸盐（ONOO-）和含硫氨基酸代谢的改变都与PD有关，我们之前已经证明亚硫酸盐和ONOO-对神经元细胞系具有协同毒性。本文提供的数据表明，亚硫酸盐和ONOO-的这种协同毒性在细胞谷胱甘肽水平消耗50%时大大增强。亚硫酸盐的毒性也略有增强。谷胱甘肽减少的神经元可能受到亚硫酸盐，特别是ONOO-和亚硫酸盐的协同破坏作用的风险增加。由于亚硫酸盐通常作为半胱氨酸代谢的产物存在于大脑中，并且由于PD中ONOO-形成增加，这些事件可能导致神经元细胞死亡。(C) 1999 Elsevier Science Inc.；
In Parkinson's disease (PD) and incidental Lewy body disease glutathione levels in the substantia nigra are decreased by 40-50%. Both peroxynitrite (ONOO-) and alterations in the metabolism of sulfur-containing amino acids have been implicated in PD and we have previously shown that sulfite and ONOO- exert synergistic toxicity to a neuronal cell line. This article presents data to show that this synergistic toxicity of sulfite and ONOO- is greatly enhanced by 50% depletion of cellular glutathione levels. The toxicity of sulfite is also slightly enhanced. Neurones with decreased glutathione may be at increased risk from sulfite and especially from the synergistic damaging effects of ONOO- and sulfite. Because sulfite is present normally in the brain as a product of cysteine metabolism, and because increased ONOO- formation has been reported in PD, these events might contribute to neuronal cell death. (C) 1999 Elsevier Science Inc.