Secondary hormonal manipulations in the management of advanced prostate cancer.

Secondary hormonal manipulations in the management of advanced prostate cancer.
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发表时间：
2005-06
期刊：
The Canadian journal of urology
影响因子：
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通讯作者：
U. Chaudhary;M. Rashid;A. Onitilo;N. Bissada
U. Chaudhary;M. Rashid;A. Onitilo;N. Bissada
中科院分区：
其他
文献类型：
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作者：
U. Chaudhary;M. Rashid;A. Onitilo;N. Bissada

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Prostate cancer is a heterogeneous disease and clinical outcomes vary considerably after failure of primary androgen ablation. With the development of new therapeutics the management of patients with androgen independent prostate cancer has changed considerably over the last few years. Multiple secondary hormonal manipulations are available and may lead to prolonged periods of clinical response. These maneuvers include the use of oral antiandrogens, antiandrogen withdrawal, ketoconazole, aminoglutethimide, corticosteroids and use of estrogenic compounds. This article reviews the clinical activity of these agents in management of patients with advanced prostate cancer.