Intrafollicular conditions as a major link between maternal metabolism and oocyte quality: a focus on dairy cow fertility
Intrafollicular conditions as a major link between maternal metabolism and oocyte quality: a focus on dairy cow fertility
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DOI：
10.1071/rd11901
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发表时间：
2012-01-01
影响因子：
1.9
通讯作者：
Bols, P. E. J.
中科院分区：
文献类型：
--
作者：
Leroy, J. L. M. R.;Rizos, D.;Bols, P. E. J.
卵母细胞和胚胎质量下降被认为是高产奶牛生育力令人失望的主要因素。本文旨在阐明卵泡内环境在奶牛低生育力问题中的重要性。产后早期能量负平衡（NEB）相关的代谢紊乱与卵巢功能障碍有关。NEB期间卵泡生长模式的变化可间接影响卵母细胞的质量。此外，母体代谢紊乱（与NEB相关或营养诱导）可能会改变卵泡液的内分泌和生化组成，卵泡液是生长和成熟的雌性配子的微环境。成熟的卵母细胞是非常敏感的任何干扰，在其直接的环境和体外成熟模型显示，这些代谢变化的一些降低卵母细胞的发育能力。此外，由于在不利条件下成熟，胚胎质量显著降低。良好平衡和定时的卵母细胞代谢和基因表达对于保障最佳卵母细胞发育至关重要。从这个角度来看，卵母细胞的代谢组和转录组参数可能有助于预测生殖成功率。最后，越来越多的证据表明，卵母细胞生长和成熟的不利条件也可能危及后代的健康和表现。
Reduced oocyte and embryo quality are recognised as major factors in the problem of disappointing fertility in high producing dairy cows. This review aims to shed more light on the importance of the intrafollicular environment in the subfertility problem in dairy cows. Metabolic disturbances associated with negative energy balance (NEB) early postpartum are associated with ovarian dysfunction. Changes in the growth pattern of the ovarian follicle during a period of NEB can indirectly affect oocyte quality. Furthermore, a maternal metabolic disorder (linked with NEB or nutritionally induced) may alter the endocrine and biochemical composition of the follicular fluid, the micro-environment of the growing and maturing female gamete. The maturing oocyte is very sensitive to any perturbation in its direct environment and in vitro maturation models revealed that some of these metabolic changes reduce the oocyte's developmental competence. Also, embryo quality is significantly reduced due to maturation in adverse conditions. Well balanced and timed oocyte metabolism and gene expression are crucial to safeguard an optimal oocyte development. In that perspective, metabolome and transcriptome parameters of the oocyte may serve to predict reproductive success rates. Finally, there is growing evidence that adverse conditions for oocyte growth and maturation may also jeopardise the health and performance of the offspring.