Radiobromine and radioiodine for medical applications
Radiobromine and radioiodine for medical applications
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DOI：
10.1515/ract-2019-0004
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发表时间：
2019-09-01
影响因子：
1.8
通讯作者：
Adam, Michael J.
中科院分区：
文献类型：
--
作者：
Wilbur, D. Scott;Adam, Michael J.
卤素溴和碘具有相似的化学性质，由于它们在元素周期表的第17族中位置很近，因此会发生相似的反应。有许多溴和碘放射性核素具有对人类疾病的诊断和治疗有用的特性。总结了半衰期超过1小时的放射性溴和放射性碘核素的发射特性，以及使放射性核素在PET/SPECT成像和β /俄歇治疗中有用的特性，以便读者可以评估哪些放射性核素可能对医学应用有用。概述了用放射性溴和放射性碘核素对分子进行放射性标记的化学方法，并举例说明。此外，还提供了利用所描述的放射性标记方法的各种不同的器官/癌症靶向剂的参考资料。
The halogens bromine and iodine have-similar chemical properties and undergo similar reactions due to their closeness in Group 17 of the periodic chart. There are a number of bromine and iodine radionuclides that have properties useful for diagnosis and therapy of human diseases. The emission properties of radiobromine and radioiodine nuclides with half-lives longer than 1 h are summarized along with properties that make radionuclides useful in PET/SPECT imaging and beta/Auger therapy, such that the reader can assess which of the radionuclides might be useful for medical applications. An overview of chemical approaches that have been used to radiolabel molecules with radiobromine and radioiodine nuclides is provided with examples. Further, references to a large variety of different organ/cancer-targeting agents utilizing the radiolabeling approaches described are provided.