Differential engagement of the ventromedial prefrontal cortex by goal-directed and habitual behavior toward food pictures in humans.
Differential engagement of the ventromedial prefrontal cortex by goal-directed and habitual behavior toward food pictures in humans.
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人类对食物图片的目标导向和习惯行为对腹内侧前额叶皮层的差异性参与。
DOI：
10.1523/jneurosci.1639-09.2009
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发表时间：
2009-09-09
期刊：
影响因子：
--
通讯作者：
Fletcher PC
中科院分区：
文献类型：
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作者：
de Wit S;Corlett PR;Aitken MR;Dickinson A;Fletcher PC
根据双系统理论，工具性学习同时受到目标导向系统和习惯系统的支持。虽然目标导向系统通过结果-行动关联的行为控制在适度训练中占主导地位，但刺激-反应关联被认为在习惯系统中同时形成。因此，在健康人类志愿者的神经影像学研究中，分离目标导向系统的神经基质具有挑战性。然而，最近，德威特和他的同事开发了一个工具辨别任务，区分目标导向和习惯导向的反应。在这个任务中，线索与后续结果一致、不相关或不一致。目标导向和习惯系统都可以支持一致性和控制试验的表现，而不一致辨别的表现则完全依赖于习惯系统。在本研究中，我们对接受功能性磁共振成像（fMRI）的健康参与者进行了这项任务，以证明学习过程中目标导向系统的参与反映在腹内侧前额叶皮层的活动增加上。此外，使用随后的结果贬值操纵，我们表明，即使在没有外部线索指导绩效的情况下，当目标价值发生变化时，该区域也参与指导决策。因此，我们可以排除腹内侧前额叶功能的纯粹巴甫洛夫解释，并明确证明它参与了目标导向知识的获取和部署。
According to dual-system accounts, instrumental learning is supported by both a goal-directed and a habitual system. Although behavioral control by the goal-directed system, through outcome-action associations, dominates with moderate training, stimulus-response associations are thought to form concurrently in the habit system. It is therefore challenging to isolate the neural substrate of the goal-directed system in neuroimaging research with healthy human volunteers. Recently, however, de Wit and colleagues developed an instrumental discrimination task, that distinguishes between goal-directed and habit-based responding. In this task, cues are congruent, unrelated or incongruent with subsequent outcomes. Whereas performance on congruent and control trials can be supported by both the goal-directed and habitual system, performance on the incongruent discrimination relies solely on the habit system. In the present study we used this task with healthy participants undergoing functional Magnetic Resonance Imaging (fMRI) to demonstrate that engagement of the goal-directed system during learning is reflected in increased activity in the ventromedial prefrontal cortex. Moreover, using a subsequent outcome devaluation manipulation, we show that this area is involved in guiding decision-making when goal values change, even in the absence of external cues to guide performance. We can therefore exclude a purely Pavlovian account of ventromedial prefrontal function and unequivocally demonstrate its involvement in the acquisition as well as deployment of goal-directed knowledge.