HLA ANTIGENS AND BF ALLOTYPES IN SLE - EVIDENCE FOR THE ASSOCIATION BEING WITH SPECIFIC HAPLOTYPES
HLA ANTIGENS AND BF ALLOTYPES IN SLE - EVIDENCE FOR THE ASSOCIATION BEING WITH SPECIFIC HAPLOTYPES
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DOI：
10.1111/j.1399-0039.1982.tb01426.x
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发表时间：
1982-01-01
期刊：
影响因子：
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通讯作者：
BATCHELOR, JR
中科院分区：
文献类型：
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作者：
BLACK, CM;WELSH, KI;BATCHELOR, JR
对67例无血缘关系的系统性红斑狼疮（SLE）患者的临床特征及HLA分型进行了分析。注意到A1、B8和DR 3的频率增加。这些抗原处于紧密连锁不平衡状态，SLE的易感性显然与所有3种抗原的存在相关，暗示了携带这些抗原的特定单倍型。DR 2的频率增加，但不是A3或B7，被证明。后2种抗原与DR 2连锁不平衡。在54例白人SLE组中，73.3%为B8和/或DR 2。对照组为37.5%，差异有显著性（P < 0.001）。疾病程度、特定器官受累和循环中抗双链DNA抗体水平与任何HLA区域产物之间无明显关联。
The clinical features and HLA types of 67 unrelated patients with systemic lupus erythematosus (SLE) were analyzed. An increase in frequencies of A1, B8 and DR3 was noted. These antigens are in close linkage disequilibrium, and susceptibility to SLE apparently is associated with the presence of all 3 antigens, implicating the specific haplotype which bears these antigens. An increase in frequency of DR2, but not A3 or B7, was demonstrated. These latter 2 antigens are in linkage disequilibrium with DR2. Of the 54 Caucasoid SLE group, 73.3% were either B8 and/or DR2. This is in comparison with 37.5% in the controls and the difference is significant (P < 0.001). There was no association apparent between extent of disease, particular organ involvement and level of circulating antibodies to double stranded DNA with any HLA region product.