Hepatoprotective Tetrahydrobenzocyclooctabenzofuranone Lignans from Kadsura longipedunculata
Hepatoprotective Tetrahydrobenzocyclooctabenzofuranone Lignans from Kadsura longipedunculata
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DOI：
10.1021/acs.jnatprod.9b00576
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发表时间：
2019-10-01
影响因子：
5.1
通讯作者：
Li, Shuai
中科院分区：
文献类型：
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作者：
Liu, Jiabao;Pandey, Pankaj;Li, Shuai
从长足海棠根中分离得到3个新的四氢苯并环八苯并呋喃甲酮木脂素糖苷，它们分别是长环八苯并呋喃木脂素A-C(1-3)，一个新的二苯并环八碳二烯木脂素D(4)，一个新的二苯并环八苯并呋喃二烯木脂素(5)，五个新的四氢苯并环八苯并呋喃酮木脂素(6-10)，以及两个新的简单木脂素(11，12)。利用MS、核磁共振以及实验和计算的电子圆二色谱数据确定了它们的结构和绝对构型。化合物7对N-乙酰-对氨基苯酚诱导的HepG2细胞毒性有一定的保护作用，10 mU M时细胞存活率为50.8%。化合物2、7和12对10 mU M的一氧化氮产生抑制率分别为55.1%、74.9%和89.8%，具有显著的体外抑制作用。
Three new tetrahydrobenzocyclooctabenzofuranone lignan glucosides, longipedunculatins A-C (1-3), a new dibenzocyclooctadiene lignan glucoside, longipedunculatin D (4), a new dibenzocyclooctadiene lignan (5), five new tetrahydrobenzocyclooctabenzofuranone lignans (6-10), and two new simple lignans (11, 12) were isolated from the roots of Kadsura longipedunculata. Their structures and absolute configurations were established using a combination of MS, NMR, and experimental and calculated electronic circular dichroism data. Compound 7 showed moderate hepatoprotective activity against N-acetyl-p-aminophenol-induced toxicity in HepG2 cells with a cell survival rate at 10 mu M of 50.8%. Compounds 2, 7, and 12 showed significant in vitro inhibitory effects with an inhibition rate of 55.1%, 74.9%, and 89.8% on nitric oxide production assays at 10 mu M.