Molecular Mechanisms of Metastasis
Molecular Mechanisms of Metastasis
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DOI：
10.1002/jso.21690
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发表时间：
2011-05-01
影响因子：
2.5
通讯作者：
Pantel, Klaus
中科院分区：
文献类型：
--
作者：
Hoon, Dave S. B.;Ferris, Robert;Pantel, Klaus
转移的机制是一组复杂的事件，这些事件彼此建立，以实现在原发性肿瘤以外的器官部位的成功生长。不同癌症转移的累积事件具有共同的和特定的癌症特异性事件。本文综述了不同癌症中与转移有关的几个关键因素，包括肿瘤抑制基因的表观遗传调控、肿瘤相关趋化因子受体的功能活性和循环肿瘤细胞。外科肿瘤学杂志2011;103：508-517. (C)2011 Wiley-Liss，Inc.
The mechanism of metastasis is a complex set of events that build upon each other to achieve successful growth in organ sites beyond the primary tumor. The cumulative events for metastasis of different cancers have both common and specific cancer specific events. This review discusses several key factors in different cancers that are responsible in metastasis, which includes epigenetic regulation of tumor suppressor genes, functional activity of tumor-related chemokine receptors, and circulating tumor cells. J. Surg. Oncol. 2011;103:508-517. (C) 2011 Wiley-Liss, Inc.