Anxiety is associated with cognitive impairment in newly-diagnosed Parkinson's disease.
Anxiety is associated with cognitive impairment in newly-diagnosed Parkinson's disease.
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DOI：
10.1016/j.parkreldis.2017.01.001
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发表时间：
2017-03
影响因子：
4.1
通讯作者：
ICICLE-PD study group
中科院分区：
文献类型：
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作者：
Dissanayaka NNW;Lawson RA;Yarnall AJ;Duncan GW;Breen DP;Khoo TK;Barker RA;Burn DJ;ICICLE-PD study group
焦虑和轻度认知障碍（MCI）是帕金森病（PD）常见的非运动表现。虽然很少有研究表明PD患者的认知功能障碍和焦虑之间可能存在联系，但据我们所知，还没有研究直接检验它们之间的联系。本研究探讨新诊断帕金森病患者的焦虑与认知缺陷之间的关系。新诊断的PD患者（N = 185）从社区和门诊诊所招募。焦虑的评估使用统一帕金森病评定量表（MDS-UPDRS）临床医生评定的焦虑项目，该项目先前已根据PD中焦虑障碍诊断的标准化标准进行了验证。得分≥2分的参与者被归类为焦虑。使用低于正常值（从对照组获得）1 SD的阈值来定义认知障碍。在每个领域≥1次测试中，特定认知领域的损伤被确定为比对照组低>1 SD。在控制了年龄、受教育程度和运动严重程度后，焦虑患者发生认知障碍的可能性是无焦虑患者的3倍（OR = 3.0, 95% CI = 1.2-7.3, p < 0.05）。与无焦虑的PD相比，焦虑患者因记忆领域的损害而被归类为认知障碍的可能性是前者的两倍多（OR = 2.3, 95% CI = 1.0-5.1, p < 0.05），而焦虑与其他认知领域的表现之间没有关联。这项研究显示了焦虑和认知障碍（特别是记忆障碍）之间的联系。研究这种关联的神经基础保证了这一发展领域的未来研究。焦虑与PD患者轻度认知障碍（MCI）相关。焦虑患者出现认知障碍的可能性是正常人的三倍。焦虑与记忆领域的损伤特别相关。
Anxiety and mild cognitive impairment (MCI) are prevalent non-motor manifestations of Parkinson's disease (PD). While few studies have demonstrated a possible link between cognitive dysfunction and anxiety in PD, to our knowledge, no studies have directly examined the association between them. This study investigated the association between anxiety and cognitive deficits in newly diagnosed PD patients. Patients with newly diagnosed PD (N = 185) were recruited from community and outpatient clinics. Anxiety was assessed using the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) clinician rated anxiety item, which has previously been validated against a standardized criteria for the diagnosis of anxiety disorders in PD. Participants scoring ≥2 were classified as anxious. A threshold of 1 SD below normative values (obtained from controls) was used to define cognitive impairment. Impairments in specific cognitive domains were identified as being >1 SD below controls in ≥1 test per domain. After controlling for age, education and motor severity, patients with anxiety were three times more likely to have cognitive impairment compared to those without anxiety (OR = 3.0, 95% CI = 1.2–7.3, p < 0.05). Patients with anxiety were more than twice as likely to be classified as having cognitive impairment due to impairment in the memory domain compared with PD without anxiety (OR = 2.3, 95% CI = 1.0–5.1, p < 0.05), whilst no associations were found between anxiety and performance on other cognitive domains. This study shows an association between anxiety and cognitive impairment (specifically memory impairment). Examining the neural basis of this association warrants future research in this developing field. Anxiety was associated with mild cognitive impairment (MCI) in PD. Patients with anxiety were three times more likely to have cognitive impairment. Anxiety was specifically associated with impairments in the memory domain.