Prolonged periods without food intake during pregnancy increase risk for elevated maternal corticotropin-releasing hormone concentrations
Prolonged periods without food intake during pregnancy increase risk for elevated maternal corticotropin-releasing hormone concentrations
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DOI：
10.1067/mob.2001.115863
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发表时间：
2001-08-01
影响因子：
9.8
通讯作者：
Dunkel-Schetter, C
中科院分区：
文献类型：
--
作者：
Herrmann, TS;Siega-Riz, AM;Dunkel-Schetter, C
目的：妊娠期间禁食刺激动物早产，并增加妇女早产的风险。禁食刺激动物下丘脑促肾上腺皮质激素释放激素的产生。母体促肾上腺皮质激素释放激素浓度升高与早产有关。研究设计：在妊娠期行为研究中，我们用多变量逻辑回归分析（n = 237）研究了妊娠期长时间不进食、促肾上腺皮质激素释放激素浓度和分娩时胎龄。在妊娠期间的两个时间点，控制妊娠前体重指数、能量摄入、收入、种族、吸烟、和母亲年龄（18-20周：校正比值比，2.5; 95% CI，0.9-7.1; 28-30周：校正比值比，1.7; 95% CI，0.7-4.2）。母亲的促肾上腺皮质激素释放激素的浓度和孕龄之间呈反比，线性关系deliver.CONCLUSIONS：在怀孕期间没有食物摄入的时间延长与母亲的促肾上腺皮质激素释放激素的浓度升高，早产。
OBJECTIVE: Fasting during pregnancy stimulates preterm delivery in animals and increases women's risk for preterm delivery. Fasting stimulates hypothalamic corticotropin-releasing hormone production in animals. Elevated maternal corticotropin-releasing hormone concentrations are associated with preterm birth. We hypothesized that prolonged periods without food during pregnancy increase maternal corticotropin-releasing hormone concentrations, which lead to preterm delivery.STUDY DESIGN: In the Behavior In Pregnancy Study, we examined prolonged periods without eating during pregnancy and corticotropin-releasing hormone concentrations and gestational age at delivery with multivariate logistic regression analysis (n = 237).RESULTS: Prolonged periods without food lasting 13 hours or longer were associated with elevated maternal corticotropin-releasing hormone concentrations compared with prolonged periods without food lasting less than 13 hours at two time points during pregnancy, controlling for pregravid body mass index, energy intake, income, race, smoking, and maternal age (18-20 weeks: adjusted odds ratio, 2.5; 95% Cl, 0.9-7.1; 28-30 weeks: adjusted odds ratio, 1.7; 95% Cl, 0.7-4.2). There was an inverse, linear relationship between maternal corticotropin-releasing hormone concentrations and gestational age at delivery.CONCLUSIONS: Prolonged periods without food intake during pregnancy are associated with elevated maternal corticotropin-releasing hormone concentrations and with preterm delivery.