Evidence for dendritic competition in the developing retina
Evidence for dendritic competition in the developing retina
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DOI：
10.1038/297683a0
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发表时间：
1982-06
期刊：
影响因子：
64.8
通讯作者：
V. Perry;R. Linden
中科院分区：
文献类型：
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作者：
V. Perry;R. Linden
目前，对树枝晶形态的调控规律知之甚少。几项研究表明，树突状细胞的形状取决于它的传入供应1，2。视网膜的神经节细胞为研究神经元发育提供了一种特别有用的细胞类型，因为它们独立于其他脑区的传入发育。如果仅在发育中的视网膜的一小块区域中就破坏了神经节细胞，就有可能研究邻近同类神经元的缺失如何影响枯竭区域周围神经节细胞的发育。视网膜正常板层模式的发育不会因这些细胞的丧失而受到干扰。我们在这里表明，枯竭区域周围的神经节细胞树突优先指向该区域。神经节细胞树突的取向受到邻近细胞的强烈影响，我们认为在正常发育过程中，树突竞争它们的传入。
At present little is known of the rules regulating dendritic morphology. Several studies have demonstrated that the shape of the dendritic tree depends on its afferent supply1,2. The ganglion cells of the retina provide a particularly useful cell type for the study of neurone development as they develop independently of afferents from other brain regions. If the ganglion cells alone are destroyed in a small patch of the developing retina, it is possible to examine how the absence of neighbouring neurones of the same type influences the development of the ganglion cells around the depleted area. The development of the normal laminar pattern of the retina is not disturbed by the loss of these cells3. We show here that the dendrites of ganglion cells around the depleted area are preferentially directed towards this region. The orientation of ganglion cell dendrites is strongly influenced by neighbouring cells and we suggest that during normal development, dendrites compete for their afferents.