Effects of Subchronic Exposure to Multi-Walled Carbon Nanotubes on Mice
Effects of Subchronic Exposure to Multi-Walled Carbon Nanotubes on Mice
复制标题
亚慢性暴露于多壁碳纳米管对小鼠的影响
DOI：
10.1080/15287390903523378
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发表时间：
2010-01-01
影响因子：
2.6
通讯作者：
Pu, Yuepu
中科院分区：
文献类型：
--
作者：
Liang, Geyu;Yin, Lihong;Pu, Yuepu
碳纳米管之所以引起人们的关注，不仅是因为其在电学、光学和机械方面的应用，还因为它们在生物和医药产品中的存在。在这项研究中，使用改性多壁碳纳米管（MWCNT）作为模型来评估碳纳米管对小鼠的潜在亚慢性影响。 ICR 小鼠每天通过腹膜内 (ip) 途径以 10、50 或 250 mg/kg 的剂量用磷酸胆碱接枝的多壁碳纳米管 (MWCNT-PC) 治疗，持续 28 天。亚慢性暴露于 MWCNT-PC 并未对小鼠产生任何明显的全身效应。高剂量组雄性小鼠的体重显着低于对照组，而肝脏、脾脏和肺的组织与体重比随着MWCNT-PC剂量的增加而显着上升。高剂量暴露组和对照组之间存在显着差异。在高剂量暴露组中观察到碳纳米管的积累以及肝脏、脾脏和肺部的炎症反应。 10 mg/kg暴露组未发现全身毒性和组织病理学变化。本研究中的数据支持这样的观点，即体内多壁碳纳米管不会对小鼠产生明显的显着影响，并且多壁碳纳米管产品对于人类食用相对安全。
Carbon nanotubes have attracted attention not only due to electrical, optical, and mechanical applications but also due to their presence in biological and pharmaceutical products. In this study, modified multi-walled carbon nanotubes (MWCNT) were used as a model to evaluate potential subchronic effects of carbon nanotubes on mice. ICR mice were treated with phosphorylcholine-grafted multi-walled carbon nanotubes (MWCNT-PC) daily for 28 d at 10, 50, or 250 mg/kg by the intraperitoneal (ip) route. Subchronic exposure to MWCNT-PC did not produce any apparent systemic effects in mice. The body weight of the high-dose group was significantly lower than control in male mice, whereas tissue to body weight ratios of liver, spleen, and lung rose significantly with increase of dose of MWCNT-PC. There were significant differences between high-dose exposure and control groups. Accumulation of carbon nanotubes and inflammation response in liver, spleen, and lung were observed in the high-dose exposure group. No systemic toxicity and histopathological changes were found in 10-mg/kg exposure groups. Data in the present study support the view that MWCNT in vivo do not exert apparent marked effects in mice and that MWCNT products are relatively safe for human consumption.