ANTI-ANGIOGENESIS - NEW CONCEPT FOR THERAPY OF SOLID TUMORS
ANTI-ANGIOGENESIS - NEW CONCEPT FOR THERAPY OF SOLID TUMORS
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DOI：
10.1097/00000658-197203000-00014
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发表时间：
1972-01-01
影响因子：
9
通讯作者：
FOLKMAN, J
中科院分区：
文献类型：
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作者：
FOLKMAN, J
在动物和人中Soto肿瘤的生长伴随着新血管形成。新的毛细血管生长是由不同的。恶性肿瘤细胞产生的融合因子。在没有新生血管形成的情况下，大多数肿瘤可能在微小直径（可能为2-3 mm）时处于休眠状态。虽然这些陈述的证据仍然是间接和零碎的，但似乎可以适当地推测，抑制血管生成，即抗血管生成，可能提供一种值得认真探索的癌症治疗形式。根据我们实验室和其他实验室最近的发现，这种论点的证据将在本报告中加以分析。
Soto tumor growth in animals and in man is accompanied by neovascularization. New capillary growth is elicited by a dif-. fusible factor generated by malignant tu-mor cells. In the absence of neovasculariza-tion most tumors might become dormant at a tiny diameter, perhaps 2–3 mm.*** Although evidence for these statements is still indirect and fragmentary, it seems appropriate to speculate that the inhibition of angiogenesis, ie, anti-angiogenesis, may provide a form of cancer therapy worthy of serious exploration. The evidence for such a contention, based on recent findings in our own laboratory and others, will be exanined in this report.