Postprandial hyperglycemia and diabetes complications - Is it time to treat?
Postprandial hyperglycemia and diabetes complications - Is it time to treat?
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DOI：
10.2337/diabetes.54.1.1
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发表时间：
2005-01-01
期刊：
影响因子：
7.7
通讯作者：
Ceriello, A
中科院分区：
文献类型：
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作者：
Ceriello, A
越来越多的证据表明，餐后状态是动脉粥样硬化发展的一个促成因素。在糖尿病中，餐后阶段的特征在于血糖水平的快速和大量增加，并且餐后“高血糖尖峰”可能与心血管并发症的发作相关的可能性最近受到了很多关注。流行病学研究和初步干预研究表明，餐后高血糖是心血管疾病（CVD）的直接和独立的危险因素。大多数心血管危险因素在糖尿病受试者的餐后阶段发生改变，并直接受到糖尿病急性增加的影响。急性高血糖症发挥其作用的机制可以在自由基的产生中确定。餐后高血糖对糖尿病并发症有害影响的证据足以影响主要专业科学协会的指南。纠正餐后高血糖可能是预防和管理糖尿病心血管疾病策略的一部分。
Increasing evidence suggests that the postprandial state is a contributing factor to the development of atherosclerosis. In diabetes, the postprandial phase is characterized by a rapid and large increase in blood glucose levels, and the possibility that the postprandial "hyperglycemic spikes" may be relevant to the onset of cardiovascular complications has recently received much attention. Epidemiological studies and preliminary intervention studies have shown that postprandial hyperglycemia is a direct and independent risk factor for cardiovascular disease (CVD). Most of the cardiovascular risk factors are modified in the postprandial phase in diabetic subjects and directly affected by an acute increase of glycemia. The mechanisms through which acute hyperglycemia exerts its effects may be identified in the production of free radicals. This alarmingly suggestive body of evidence for a harmful effect of postprandial hyperglycemia on diabetes complications has been sufficient to influence guidelines from key professional scientific societies. Correcting the postprandial hyperglycemia may form part of the strategy for the prevention and management of CVDs in diabetes.